(1) Nanoparticles in basic medicine research clinical diagnosis/therapeutics, particularly in non-invasive imaging, targeting drug delivery and controlled release.
(2) Mechanistic studies and clinical applications of transdermal delivery/sampling
(3) Implantable ?-device for minimally invasive sampling and/or in situ analysis to study various physiological disorders
(4) Integrated biomedical microchip for on-line and high throughput analysis
5) Damage mechanisms and therapeutic approaches of organ ischemia and reperfusion: such as stroke, acute myocardial infarction and liver ischemia/reperfusion
1. Synthesis of polymer-based vehicles for drug delivery
2. Preparation of dendrimer-encapsulated nanodots
3. Functionalized nanomaterials and nanodots for sensing biological events
4. Analytical chemistry
5. Surface chemistry
本實驗室主要以貴重金屬奈米微粒的物理化學特性研究為根基(學術研究1),探索生物超分子自組裝/共組裝的分子機制,以化學尺度理解生物超分子的自我和他我之間的平衡態/非平衡態的相互作用與疾病的關連性(學術研究2),並以此根基提供藥物設計的對策(應用研究1)。另外,本實驗室也在傷口癒合的生醫材料中,植入具催化特性及功能性的奈米微粒(學術研究3),發展會呼吸的傷口治療敷料,促使傷口微環境的自我修護(應用研究3)。最近,也著眼於抗肥胖微針的增加脂肪產熱效應醫材的開發(應用研究3)。最後,本實驗在具功能性奈米藥物遞送系統的開發有基礎(應用研究4),歡迎有興趣合作的實驗室與我們聯絡。