羅履維 博士

羅履維 博士

研究員

辦公室分機 37115

實驗室分機 37116

lwlo@nhri.edu.tw

實驗室網站 

Education

  • 1992 - 1996
    School of Medicine, University of Pennsylvania, USA
    Ph.D., Molecular Biophysics
  • 1990 - 1992
    University of Massachusetts, USA
    M.S., Biochemistry/Chemistry
  • 1983 - 1987
    Tamkang University, Taiwan
    B.S., Applied Chemistry

Professional Experiences

  • 2011
    Department of Radiology and Comprehensive Cancer Center, The University of Chicago, IL, USA
    Visiting Professor
  • 2010 - present
    Division of Medical Engineering, National Health Research Institutes, Taiwan
    Investigator
  • 2010 - present
    Institute of Electro-Optical Engineering, National Chiao-Tung University, Taiwan
    Adjunct Professor
  • 2009 - 2010
    Computing and Information Center, Department of Administration, National Health Research Institutes, Taiwan
    Acting Director
  • 2008 - 2010
    Institute of Electro-Optical Engineering, National Chiao-Tung University, Taiwan
    Adjunct Associate Professor
  • 2006 - 2010
    Division of Medical Engineering, National Health Research Institutes, Taiwan
    Associate Investigator
  • 2001 - 2006
    Division of Medical Engineering, National Health Research Institutes, Taiwan
    Assistant Investigator
  • 2001 - 2006
    Institute of Biomedicine and Biomedical Technology, National Chi-Nan University, Taiwan
    Adjunct Assistant Professor
  • 2000 - 2001
    Department of Applied Chemistry, National Chi-Nan University, Taiwan
    Assistant Professor
  • 1997 - 2000
    Institute of Biomedical Sciences, Academic Sinica, Taiwan
    Postdoctoral Fellow in Cardiovascular Research

Research Interests

Dr. Lo's major research interests, with multidisciplinary approaches, converge in the field of Nano/Biophotonics, especially in applying in vivo spectroscopy and optical imaging with novel nanoparticulates towards prognoses and therapeutics of various diseases such as cancer and central nervous system injury.
Keywords: Nanomedicine; Nanotheranostics; Biophotonics; Drug Targeted Delivery and Controlled Release; Molecular Imaging

Research Activities & Accomplishment

Dr. Lo's research accomplishment could be described in a generic and panoramic scheme as of "Nanoparticle-modulated In Vivo Biophotonics Sensing and Imaging for Translational Theranostics". It's an effort to synergize emerging biophotonics and nanotechnology towards medical solutions, from basic to bedside, namely translational innovations. Tri-functionalization of novel nanoparticles, especially mesoporous silica nanoparticles (MSNs), orchestrates the trio of imaging, targeted delivery and therapy. Such a 3-in-1 approach facilitates and realizes the advance of comprehensive theranostics, i.e., the dual diagnostic and therapeutic utility of a compound or methodology, in clinical translation of nanomedicine.

Selected Publications

  1. Cheng, S.H., Yu, D, Tsai, H.M., Morshed R.A., Kanojia, D., Lo, L.W., Leoni, L., Govind, Y., Zhang, L., Aboody, K.S., Lesniak, M.S., Chen, C.T., Balyasnikova, I.V. (2015) Dynamic in vivo SPECT imaging of neural stem cells functionalized with radiolabeled nanoparticles for tracking of glioblastoma. J. Nucl. Med. November 12, jnumed.115.163006.

  2. Lin, C.Y., Huang, J.Y. and Lo, L.W. (March, 2015) Unraveling the impact of lipid domains on the dimerization processes of single-molecule EGFRs of live cells. Biochimica et Biophysica Acta - Biomembranes 1848(3): 886-893.

  3. Lin, C.Y., Huang, J.Y. and Lo, L.W. (December 7, 2014) Energetic modeling and single-molecule verification of dynamic regulation on receptor complexes by actin corrals and lipid raft domains. J. Chem. Phys. 141(21): 215102. doi: 10.1063/1.4902985.

  4. Souris, J.S., Cheng, S.H., Pelizzari, C., Chen, N. T., La Riviere, P., Chen, C. T., and Lo, L.W.* (20, November, 2014) Radioluminescence characterization of in situ x-ray nanodosimeters: potential real-time monitors and modulators of external beam radiation therapy. Appl. Phys. Lett. 105(20): 203110-5.

  5. Chung, M.F., Huang, C.M., Souris, J.S., and Lo, L.W.* (5, November, 2014) Controlled epitaxial growth of heterogeneous gold nanorod-mesoporous silica core-shell nanolollipop and nanodumbbell. APL Materials 2(11): 113312-8.

  6. Sivasubramanian, M. and Lo, L.W.* (2014) Silicon nanowires for green energy applications. Curr. Org. Chem. 18(18): 2442-2450.

  7. Cheng, S.H., Chu, C.H., Chen, N.T., Souris, J.S., Chen, C.T., and Lo, L.W.* (2014) Significant inhibition of tumor growth following single dose nanoparticle-enhanced photodynamic therapy. Int. J. Photoenergy vol. 2014, Article ID 297129, 11 pages, 2014. Doi:10.1155/2014/297129.

  8. Chen, N.T., Tang, K.C., Chung, M.F., Cheng, S.H., Huang, C.M., Chu, C.H., Chou, P.T., Souris, J.S., Chen, C.T., Mou, C.Y., and Lo, L.W.* (2014) Enhanced plasmonic resonance energy transfer in mesoporous silica-encased gold nanorod for two-photon-activated photodynamic therapy. Theranostics 4(8): 798-807.

  9. Souris, J.S., Chen, N.T., Cheng, S.H., Chen, C.T., and Lo, L.W.* (March 27, 2014) “Silica nanoparticle platform” in Cancer Theranostics Ch. 20: 363-391, Shawn Chen and Stephen Wong, Ed., San Diego/London/Waltham: Academic Press is an imprint of Elsevier (ISBN: 978-0-12-407722-5)

  10. Cheng, Y., Morshed, R., Cheng, S.H., Tobias, A., Auffinger, B., Wainwright, D.A., Zhang, L., Yunis, C., Han, Y., Chen, C.T., Lo, L.W., Aboody, K.S., Ahmed, A.U., Lesniak, M.S. (December 20, 2013) Nanoparticle-programmed self-destructive neural stem cells in glioblastoma targeting and therapy. Small 9(24): 4123-4129.

  11. Lin, C.Y., Huang, J.Y. and Lo, L.W. (October, 2013) Deciphering the catalysis-associated conformational changes of human adenylate kinase 1 with single-molecule spectroscopy. J. Phys. Chem. – B 117(45): 13947–13955.

  12. Lin, F.S., Liu, C.P., Tseng, S.Y., Luo, C.W., Chen, C.H., Chen, J.K., Tseng, F.G., Hwu, Y.K.; Lo, L.W., Yang, C.S., Lin, S.Y. (2013) In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells. Macromolecular Bioscience 13(10): 1314-1320.

  13. Chen, N.T., Cheng, S.H., Souris, J.S., Chen, C.T., Mou, C.Y., and Lo, L.W.* (2013) Theranostic applications of mesoporous silica nanoparticles and their organic/inorganic hybrids J. Mater. Chem. B 1(25): 3128-3135.

  14. Wu, L.C., Chu, L.W., Lo, L.W., Liao, Y.C., Wang, Y.C., and Yang, C.S. (January 22, 2013) Programmable cellular retention of nanoparticles by replacing the synergistic anion of transferrin. ACS Nano 7(1): 365-75.

  15. Chen, N.T., Cheng, S.H., Liu, C.P., Souris, J.S., Chen, C.T., Mou, C.Y., and Lo, L.W.* (2012) Recent advances in nanoparticle-based Förster resonance energy transfer for biosensing, molecular imaging, and drug release profiling. Int. J. Mol. Sci. 13: 16598-16623.

  16. Chen, N.T., Wu, C.Y., Chung, C.Y., Hwu, Y.K., Cheng, S.H., Yang, C.S., Mou, C.Y., Lo, L.W.* (2012) Dynamic monitoring of doxorubicin-DNA intercalation during apoptotic initiation using fluorescence lifetime imaging microscopy. PLoS One 7(9): e44947.

  17. Huang, C.M., Cheng, S.H., Jeng, U.S., Yang, C.S., and Lo, L.W.* (2012) Formation of CdSe/CdS/ZnS–Au/SiO2 dual-yolk/shell nanostructures through a trojan–type inside-out etching strategy. Nano Res. 5(9): 654–666.

  18. Hsieh, H.Y., Huang, T.W., Xiao, J.L., Yang, C.S., Chang, C.C., Chu, C.C., Lo, L.W., Wang, S.H., Wang, P.C., Chieng, C.C., Lee, C.H., and Tseng, F.G. (2012) Fabrication and modification of dual-faced nano-mushrooms for tri-functional cell theranostics: SERS/fluorescence signaling, protein targeting, and drug delivery. J. Mater. Chem. 22: 20918-20928.

  19. Cheng, S.H., Li, F.C., Souris, J.S., Yang, C.S., Tseng, F.G., Lee, H.S., Dong, C.Y., and Lo, L.W.* (2012) Visualizing dynamics of sub-hepatic distribution of nanoparticles using intravital multiphoton fluorescence microscopy. ACS Nano 6 (5): 4122–4131.

  20. Cheng, S.H., Hsieh, C.C., Chen, N.T., Chu, C.H., Huang, C.M., Chou, P.T., Tseng, F.G., Yang, C.S., Mou, C.Y., and Lo, L.W.* (December, 2011) Well-defined mesoporous nanostructure modulates three-dimensional interface energy transfer for two-photon activated photodynamic therapy. Nano Today 6(6): 552-563.

  21. Lin, S.Y, Wu, T.H., Jao, Y.C., Liu, C.P., Lin, H.Y., Lo, L.W., and Yang, C.S. (2011) Unraveling the photoluminescence puzzle of PAMAM dendrimers. Chem.-Eur. J. 17(26): 7158-7161.

  22. Wu, C.Y., Huang, C.K., Chung, C.Y., Huang, I.P., Hwu, Y.K., Yang, C.S., Lo, L.W.*, and Chiang, S.Y. (2011) Probing the binding kinetics of proinflammatory cytokine–antibody interactions using dual color fluorescence cross correlation spectroscopy. Analyst 136(10): 2111-2118.

  23. Huang, I.P., Sun, S.P., Cheng, S.H., Lee, C.H., Wu, C.Y., Yang, C.S., Lo, L.W.,* and Lai, Y.K. (2011) Enhanced chemotherapy of cancer using pH-sensitive mesoporous silica nanoparticles to antagonize P-glycoprotein-mediated drug resistance. Mol. Cancer Ther. 10: 761-769.

  24. Lee, C.H., Cheng, S.H., Huang, I.P., Souris, J.S., Yang, C.S., Mou, C.Y., and Lo, L.W.* (2010) Intracellular pH-responsive mesoporous silica nanoparticles for controlled release of anticancer chemotherapeutics. Angew. Chem. Int. Edit. 49: 8214-8219.

  25. Lin, S.Y., Chen, N.T., Sum, S.P., Chang, C.H., Wang, Y.C., Yang, C.S., and Lo, L.W.* (2010) The protease-mediated nucleus shuttle of sub-nanometer gold quantum dot for real-time monitoring of apoptotic cell death. J. Am. Chem. Soc. 132(24): 8309-8315.

  26. Cheng, S.H., Chen, M.C., Lee, C.H., Souris, J.S., Tseng, F.G., Mou, C.Y., Yang, C.S., Chen, C.T., and Lo, L.W.* (2010) Tri-functionalization of mesoporous silica nanoparticles for comprehensive cancer theranostics- the trio of imaging, targeting and therapy. J. Mater. Chem. 20: 6149-6157.

  27. Souris, J.S., Lee, C.H., Cheng, S.H., Chen. C.T., Yang, C.S., Ho, J-a.A., Mou, C.Y., and Lo, L.W.* (2010) Surface charge dependent hepatobiliary excretion of fluorescent mesoporous silica nanoparticles for use as traceable drug delivery platforms. Biomaterials 31: 5564-5574.

  28. Chen, L.C., Chen, W.W., Souris, J.S., Cheng, S.H., Yang, C.S., Chen, C.T., Li, P.C., and Lo, L.W.* (January/February, 2010) Enhanced photoacoustic stability of gold nanorods by silica matrix confinement. J. Biomed. Opt. 15(1): 016010.

  29. Tai, L.A., Tsai, P.J., Wang, Y.C., Wang, Y.J., Lo, L.W. and Yang, C.S. (March, 2009) Thermosensitive liposomes entrapping iron oxide nanoparticles for controllable drug release. Nanotechnology. 20(12): 135101-135109.

  30. Cheng, S.H., Lee, C.H., Yang, C.S., Tseng, F.G., Mou, C.Y., and Lo, L.W.* (2009) Mesoporous silica nanoparticles functionalized with oxygen-sensing probe for cell photo-therapy as potential cancer theranostics. J. Mater. Chem. 19(9): 1252-1257.

  31. Lee, C.H., Cheng, S.H., Wang, Y.J., Chen, Y.C., Chen, N.T., Souris, J.S., Chen, C.T., Mou, C.Y., Yang, C.S., and Lo, L.W.* (2009) Near-infrared mesoporous silica nanoparticles for optical imaging: characterization and in vivo biodistribution. Adv. Funct. Mater. 19(2): 215-222.

  32. Tu, H.L., Lin, Y.S., Lin, H.Y., Hung, Y., Lo, L.W., Chen, Y.F., and Mou, C.Y. (2009) In-vitro studies of functionalized mesoporous silica nanoparticles for photodynamic therapy. Adv. Mater. 21(2): 172-177.

  33. Wang, Y.C., Wu, Y.T., Huang, H.Y., Lin, H.I., Lo, L.W., Tzeng, S.F., and Yang, C.S. (2008) Sustained intraspinal delivery of neurotrophic factor encapsulated in biodegradable nanoparticles following contusive spinal cord injury. Biomaterials 29: 4546-4553.

  34. Lin, S.Y., Chen, N.T., Sum, S.P., Lo, L.W.*, and Yang, C.S.* (2008) Ligand-exchanged photoluminescent gold quantum dots functionalized with leading peptide for nuclear targeting and intracellular imaging. Chem. Commun. 39: 4762-4764.

  35. Lee, C.H., Lo, L.W., Mou, C.Y., and Yang, C.S. (2008) Synthesis and characterization of positive-charge functionalized mesoporous silica nanoparticles for oral drug delivery of an anti-inflammatory drug. Adv. Funct. Mater. 18: 3283-3292.

  36. Lo, L.W., Tsai, P.J., Huang, S.H., Wang, Y.T., Chang, C.H., and Yang, C.S. (2005) In vivo monitoring of fluorescent nanosphere delivery in anesthetized rats using an implantable fiber-optic microprobe. Anal. Chem. 77(4): 1125-1131.

  37. Yang, C.S., Chang, C.H., Tsai, P.J., Chen, W.Y., Tseng, F.G., and Lo, L.W.* (2004) Nanoparticle-based in vivo investigation on blood-brain barrier permeability under ischemia and reperfusion. Anal. Chem. 76(15):4465-4471.

National Health Research Institutes - Institutional Repository: http://ir.nhri.org.tw/handle/3990099045/672

Patent

  1. Cheng, S.H.; Liao, W.N.; Yang, C.S., Lo, L.W. “Mesoporous silica nanoparticles for oil absorption” (a) US (USPTO) issued on 2015/11/17 with patent number: US 9,185,928 B2; (b)Taiwan (ROC) filed on 2013/12/20 with filing number: 102147599; (c)PCT publication dated on 2014/06/26 with publication number WO 2014/100522 A1.

  2. Lee, C. H.; Cheng, S. H.; Liao, W, N.; Chen, J. K.; Yang, C. S.; Lo, L. W.; Hwu, Y.; Lin, F. S. “Solid phase gold nanoparticle synthesis” (a) US (USPTO) filed on 2011/05/17 with filing number: 13/109,438; (b) Taiwan (ROC) filed on 2011/0/18 with filing number: 100117467.

  3. Lee, C. H.; Mou C. Y.; Lo, L. W.; Yang, C. S. “Drug delivery system” (a) US (USPTO) filed on 2009/10/20 with filing number: 12/581,965, Notice of Allowance on 2012/07/09; (b) Taiwan (ROC) filed on 2008/10/23 with filing number: 097140731.

  4. Tai, L. A.; Lo, L. W.; Yang, C. S.; Wang, Y. J.; Wu, Y. T.; Wang, Y. C. ”Transdermal Delivery Nanocapsules” (a) US (USPTO) issued on 2011/11/22 with patent number: US 8,062,663; (b) Taiwan (ROC) filed on 2009/05/21 with filing number:09811685, Notice of Allowance on 2012/06/26.

  5. Lin, S. Y.; Lo, L. W.; Yang, C. S. “Method for making a ligand-quantum dot conjugate” (a) US (USPTO) issued on 2012/07/10 with patent number: US8,216,549; (b) Taiwan (ROC) filed on 2009/7/22 with filing number:098124701.

  6. Lo, L. W.; Yang, C. S. “Blood flow control system, Tension adjustable Instrument and Method Thereof” (a) Taiwan (ROC) filed on 2008/07/14 with filing number: 97126701, Notice of Allowance on 2012/08/30; (b) US (USPTO) filed on 2008/05/30 with filing number: 12/219,973, Notice of Allowance on 2012/04/11.

  7. Lo, L. W.; Yang, C. S.; Chen, P. R.; Tsai, P. J. “A biodegradable material with nanopores and electric conductivity and the fabricating method thereof” (a) Taiwan (ROC) filed on 2007/01/05 with filing number: 96100482; (b) Europe (EPO) patent issued on 2009/10/14 with European patent No: 1970077 (Design state: United Kingdom).

  8. Lo, L. W.; Yang, C. S. “Implantable Microdevice for detecting, activating and delivering molecules” US (USPTO) filed on 2007/10/09 with filing number: 11/869,053.