林淑宜 博士

林淑宜 博士

研究員

辦公室分機 38127

實驗室分機 38125

shuyi@nhri.edu.tw

實驗室網站 

Education and Professional Experiences

  • 2018 - present
    Institute of Biomedical Engineering and Nanomedicine, NHRI
    Investigator
  • 2013 - 2018
    Institute of Biomedical Engineering and Nanomedicine, NHRI
    Associate Investigator
  • 2009 - 2013
    Center for Nanomedicine Research, NHRI
    Assistant Investigator
  • 2007 - 2008
    Center for Nanomedicine Research, NHRI
    Postdoctoral Fellow
  • 2006 - 2007
    National Taiwan University
    Postdoctoral Fellow
  • 2003 - 2006
    National Tsing Hua University
    Postdoctoral Fellow
  • 2000 - 2002
    Department of Chemistry, National Tsing Hua University
    Ph.D. in Chemistry
Research Interests
1.   Synthesis of polymer-based vehicles for drug/siRNA delivery
2.   Preparation of dendrimer-encapsulated nanodots
3.   Functionalized nanomaterials and nanodots for sensing biological events
4.   Analytical chemistry
5.  Surface chemistry
 
Research Activities & Accomplishment
2011 第八屆國家新創獎 (the 8th Taiwan Innovation Award)
2014 科技部優秀年青學者研究計畫/生技醫藥國家型研究計畫之個人計畫
2015 第十二屆國家新創獎 (the 12th Taiwan Innovation Award)
2016 第十四屆有庠科技論文獎 (the 14th Y. Z. Hsu Science Award)
2017 2017臺北生技獎「技轉合作獎優等獎」
 

Selected Publications

  1. "Self-Supplying O2 through the Catalase-Like Activity of Gold Nanoclusters for Photodynamic Therapy against Hypoxic Cancer Cells" Liu, C.-P.; Liu, C.-Y.; Wu, T.-H.; Chen, Y.-X.; Chen, G.-S.; Lin, S.-Y.* Manuscript in preparation.
  2. "Corrosion-Activated Nanoparticulate Platinum as a Chemotherapeutic Prodrug Overcomes Drug-Resistance by Limited Autophagy Induction" Cheng, H. –J.; Wu, T.-H. Chie, C.-T.; Tu, H.-W.; Cha, T.-S.; Lin, S.-Y.* Small, 2016, Manuscript Acceptance. (SCI: 8.315; 5-Year IF: 8.375 2015 Rank: 17/163)
  3. "Tailoring enzyme-like activities of gold nanoclusters by polymeric tertiary amines for protecting neurons against oxidative stress" Liu, C.-P.; Lin, Y.-L.; Wu, T.-H.; Liu, C.-Y.; Wang, S.; Lin, S.-Y.* Small, 2016, DOI: 10.1002/smll.201503919. (SCI: 8.315; 5-Year IF: 8.375 2015 Rank: 17/163)
  4. "Designed Nucleus Penetrating Thymine-Capped Dendrimers: A Potential Vehicle for Intramuscular Gene Transfection" Yan, J.-Y.; Wu, Z.-W.; Liu, C.-Y.; Chien, C.-T.; Chiu, W.-C.; Lin, S.-Y.* J. Mater. Chem. B, 2015, 3, 9060–9066. (SCI: 4.872; 5-Year IF: 4.879; 2015 Rank: 4/33)
  5. "Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Supramolecular Lipopolysaccharide Assembly for Modulating Immunological Responses" Luo,Y.-H.; Wu, Z. -W.; Tsai, H.-T.; Lin, S.-Y.*; Lin, P.* Nano Lett., 2015, 15, 6446–6453. (SCI: 13.779; 5-Year IF: 14.867; 2015 Rank: 7/163)
  6. "Identification of substituted naphthotriazolediones as novel tryptophan 2,3-dioxygenase (TDO) inhibitors through structure-based virtual screening" Wu, J.-S.; Lin, S.-Y.; Liao, F.-Y.; Hsiao, W.-C.; Lee, L.-C.; Peng, Y.-H.; Hsieh, C.-L.; Wu, M.-H.; Song, J.-S.; Yueh, A.; Chen, C.-H.; Yeh, S.-H.; Liu, C.-Y.; Lin, S.-Y.; Yeh, T.-K.; Hsu, T.-A.; Shih, C.; Ueng, S.-H.; Hung, M.-S.; Wu, S.-Y.* J. Med. Chem., 2015, 58, 7807–7819. (SCI: 5.589; 5-Year IF: 5.624; 2015 Rank: 3/59)
  7. "Interactions of Nitroxide Radicals with Dendrimer-entrapped Au8-clusters: A Fluorescent Nanosensor for Intracellular Imaging of Ascorbic Acid" Liu, C.-P.; Wu, T.-H.; T.-H.; Liu, C.-Y.; Lin, S.-Y.* J. Mater. Chem. B, 2015, 3, 191–197. (SCI: 4.872; 5-Year IF: 4.879; 2015 Rank: 4/33)
  8. "Co-caged gold nanoclusters and methyl motifs lead to detoxification of dendrimers and allow cytosolic access for siRNA transfection" Chien, C.-T.; Liu, C.-Y.; Wu, Z.-W.; Chen, P.-J.; Chu, C.-L.*; Lin, S.-Y.* J. Mater. Chem. B, 2014, 2, 6730–6737. (SCI: 4.872; 5-Year IF: 4.879; 2015 Rank: 4/33)
  9. "Live-Cell Imaging of Biothiols via Thiol/Disulfide Exchange to Trigger the Photoinduced Electron Transfer of Gold-Nanodot Sensor" Liu, C.-P.; Wu, T.-H.; T.-H.; Liu, C.-Y.; Lin, S.-Y.* Analytica Chimica Acta, 2014, 849, 57–63. (SCI: 4.712; 5-Year IF: 4.841; 2015 Rank: 8/75)
  10. "Fluorescent Hydroxylamine Derived from Fragmentation of PAMAM Dendrimers for Intracellular Hypochlorite Recognition" Wu, T.-H.; Jao, Y.-C.; Liu, C.-P.; Chien, C.-T.u Lin, S.-Y.* uhem. Eur. J. 2013, 19, 11672–11675. (SCI: 5.771; 5-Year IF: 5.572; 2015 Rank: 24/168)
  11. "Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics" Chien, C.-T.; Yan, J.-Y.; Ching, W.-C.; Wu, T.-H.; Liu, C.-Y.; Lin, S.-Y.* Adv. Mater. 2013, 25, 5067–5073. (SCI: 18.960; 5-Year IF: 18.862; 2015 Rank: 6/163)
  12. "In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells" Liu, C.-P.; Lin, F.-S.; Chien, C.-T.; Tseng, S.-Y.; Luo, C.-W.; Chen, C.-H.; Chen, J.-K.; Tseng, F.-G.; Hwu, YK; Lo, L.-W.; Yang, C.-S.; Lin, S.-Y.* Macromol. Biosci. 2013, 13, 1314–1320. (SCI: 3.680; 5-Year IF: 3.656; 2015 Rank: 11/85)
  13. "Cadmium-based quantum dot induced autophagy formation for cell survival via oxidative stress" Luo, Y.-H.; Wu, S.-B.; Wei, Y.-H.; Chen, Y.-C.; Tsai, M.-H.,; Ho, C.-C.; Lin, S.-Y.; Yang, C.-S.; Lin, P.* Chem. Res. Toxicol. 2013, 26, 662–673. (SCI: 3.625; 5-Year IF: 3.610; 2015 Rank: 13/83)
國家衛生研究院機構典藏: http://ir.nhri.org.tw/handle/3990099045/3715
National Health Research Institutes - Institutional Repository
 
Patent in NHRI
1.   "Method for making a ligand-quantum dot conjugate" US(USPTO) issued on 2012/07/10 with patent number: US8,216,549; "功能化量子點及其製備方法" Taiwan (ROC) filed on 2013/04/11 with patent number: I 392869,Lin, S.-Y. Lo, L.-W.; Yang, C.-S.
2.   "Single-monomer Derived Linear-like Copolymer Comprising synthesis of linear-like Polyethylenimine and Poly(ethylene glycol) for Nuclear Acid Delivery" US(USPTO) issued on 2013/06/11 with patent number: US8,4613,224; "用於核酸遞送之包含聚乙烯亞胺及聚乙二醇的單一單體衍生之類線狀共聚物" Taiwan (ROC) issued on 2014/2/11 with patent number I 426085.
3.   "Caged platinum nanocluster for anticancer chemotherapeutics/抗癌化學治療之籠狀鉑奈米團" Lin. S-Y.US(USPTO) filed on 2014/02/18 with filing number: 14/182,532; Taiwan (ROC) filed on 2014/02/19 with filing number: 103105579; PCT filed on 2014/02/18 with filing number: PCT/US14/16826 (entering national phase).
4.   "Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Lipopolysaccharide Assembly for Modulating Immunological Responses/內毒素奈米微粒: 親水性奈米金控制內毒素聚集結構形成奈米微粒進而調節免疫反應" US(USPTO)/Taiwan filed on 14/03/2016 and 03/03/2016 with filing number 15/069,946 and 105106483, respectively; Luo, -Y.-H.; Lin, S.-Y.; Lin, P.P.