林淑宜 博士

林淑宜 博士

研究員

辦公室分機 38127

實驗室分機 38125

shuyi@nhri.edu.tw

實驗室網站 

Education and Professional Experiences

  • 2018 - present
    Institute of Biomedical Engineering and Nanomedicine, NHRI
    Investigator
  • 2013 - 2017
    Institute of Biomedical Engineering and Nanomedicine, NHRI
    Associate Investigator
  • 2009 - 2013
    Center for Nanomedicine Research, NHRI
    Assistant Investigator
  • 2007 - 2008
    Center for Nanomedicine Research, NHRI
    Postdoctoral Fellow
  • 2006 - 2007
    National Taiwan University
    Postdoctoral Fellow
  • 2003 - 2006
    National Tsing Hua University
    Postdoctoral Fellow
  • 2000 - 2002
    Department of Chemistry, National Tsing Hua University
    Ph.D. in Chemistry

Research Interests

  1. Synthesis of polymer-based vehicles for drug/siRNA delivery
  2. Preparation of dendrimer-encapsulated nanodots
  3. Functionalized nanomaterials and nanodots for sensing biological
  4. Analytical chemistry
  5. Surface chemistry
    6. 本實驗室主要以貴重金屬奈米微粒的物理化學特性研究為根基(學術研究1)，探索生物超分子自組裝/共組裝的分子機制，以化學尺度理解生物超分子的自我和他我之間的平衡態/非平衡態的相互作用與疾病的關連性(學術研究2)，並以此根基提供藥物設計的對策(應用研究1)。另外，本實驗室也在傷口癒合的生醫材料中，植入具催化特性及功能性的奈米微粒(學術研究3)，發展會呼吸的傷口治療敷料，促使傷口微環境的自我修護(應用研究2)。最近，也著眼於抗肥胖微針的增加脂肪產熱效應醫材的開發(應用研究3)。最後，本實驗在具功能性奈米藥物遞送系統的開發有基礎(應用研究4)，歡迎有興趣合作的實驗室與我們聯絡。

Research Activities & Accomplishment

2011 第八屆國家新創獎 (the 8th Taiwan Innovation Award)

2014 科技部優秀年青學者研究計畫/生技醫藥國家型研究計畫之個人計畫 (Grant for Outstanding Chemistry Specialists and NRPB grant from the Ministry of Science and Technology)

2015 第十二屆國家新創獎 (the 12th Taiwan Innovation Award)

2016 第十四屆有庠科技論文獎 (the 14th Y. Z. Hsu Science Award)

2017 2017臺北生技獎「技轉合作獎優等獎」 (2017 Taipei Biotech Technology Transfer Special Mention Award)

2017 科技部傑出獎 (2017 Outstanding Research Award of Ministry of Science and Technology (MOST) of Taiwan)

2020 科技部未來科技獎

Selected Publications

  1. "Supramolecular Bait to Trigger Non-equilibrium Co-assembly and Clearance of Aβ42" Wu, T.-H.; Lai, R.-H.; Yao, C.-N.; Juang, J.-L*; Lin, S.-Y.* Angew. Chem. Int. Ed. 2020, On-line publish: https://doi.org/10.1002/anie.202013754
  2. "A Supramolecular Trap to Increase the Antibacterial Activity of Colistin" Liao, F.-H.; Wu, T.-H.; Yao, C.-N.; Kuo, S.-C.; Su, C.-J.; Jeng, U.-S.; Lin, S.-Y.* Angew. Chem. Int. Ed. 2020, 59, 1430 –1434. (SCI: 12.257; 5-Year IF: 12.359; 2018, Rank: 17/172)
  3. "Highly Efficient and Tumor-Selective Nanoparticles for Dual-Targeted Immunogene Therapy against Cancer" Huang, K.-W.; Hsu, F.-F.; Qiu, J.-T Timothy; Chern, G.-J.; Huang, Y.-T.; Sung, Y.-C.; Chiang, C.-C.; Huang, R.-L., Lin, C.-C., Lee, Y.-A., Dinh, T.-K.; Huang, H.-C., Chen, Y.-S.; Lin, S.-Y.*, Chen, Y.-C.* Science Advances 2020; 6: eaax5032. (SCI: 12.804; 5-Year IF: 13.293; 2018, 4/69)
  4. "The Bioactive Core and Corona Synergism of Quantized Gold Enables Slowed Inflammation and Increased Tissue Regeneration in Wound Hypoxia" Yeh, L.-C.; Chen, S.-P.; Liao, F.-H.; Wu, T.-H.; Huang, Y.-T.; Lin, S.-Y.* International Journal of Molecular Sciences 2020, 21(5), 1699. (SCI: 4.556; 5-Year IF: 4.653; 2019, Rank: 74/297)
  5. "Subnanometer Gold Clusters Adhere to Lipid A for Protection against Endotoxin-induced Sepsis" Liao,F.-H; Wu, T.-H.; Huang, Y.-T.; Lin, W.-J.; Su, C.-J.; Jen, U.-S; Kuo, S.-C.; Lin, S.-Y.* Nano Lett. 2018, 18, 2864-2869. (SCI: 12.080; 5-Year IF: 14.201; 2017 Rank: 15/171)
  6. "Self-Supplying O2 through the Catalase-Like Activity of Gold Nanoclusters for Photodynamic Therapy against Hypoxic Cancer Cells" Liu, C.-P.; Liu, C.-Y.; Wu, T.-H.; Chen, Y.-X.; Chen, G.-S.; Lin, S.-Y.* Small, 2017, 13, 1700278. (SCI: 8.643; 5-Year IF: 8.296 2016 Rank: 18/166)
  7. "Corrosion-Activated Nanoparticulate Platinum as a Chemotherapeutic Prodrug Overcomes Drug-Resistance by Limited Autophagy Induction" Cheng, H. –J.; Wu, T.-H. Chie, C.-T.; Tu, H.-W.; Cha, T.-S.; Lin, S.-Y.* Small, 2016, 2, 6124-6133. (SCI: 8.643; 5-Year IF: 8.296 2016 Rank: 18/166)
  8. "Tailoring enzyme-like activities of gold nanoclusters by polymeric tertiary amines for protecting neurons against oxidative stress" Liu, C.-P.; Lin, Y.-L.; Wu, T.-H.; Liu, C.-Y.; Wang, S.; Lin, S.-Y.* Small, 2016, 23, 4127–4135. (SCI: 8.643; 5-Year IF: 8.296 2016 Rank: 18/166)
  9. "Designed Nucleus Penetrating Thymine-Capped Dendrimers: A Potential Vehicle for Intramuscular Gene Transfection" Yan, J.-Y.; Wu, Z.-W.; Liu, C.-Y.; Chien, C.-T.; Chiu, W.-C.; Lin, S.-Y.* J. Mater. Chem. B, 2015, 3, 9060–9066. (SCI: 4.872; 5-Year IF: 4.879; 2015 Rank: 4/33)
  10. "Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Supramolecular Lipopolysaccharide Assembly for Modulating Immunological Responses" Luo,Y.-H.; Wu, Z. -W.; Tsai, H.-T.; Lin, S.-Y.*; Lin, P.* Nano Lett., 2015, 15, 6446–6453. (SCI: 13.779; 5-Year IF: 14.867; 2015 Rank: 7/163)
  11. "Interactions of Nitroxide Radicals with Dendrimer-entrapped Au8-clusters: A Fluorescent Nanosensor for Intracellular Imaging of Ascorbic Acid" Liu, C.-P.; Wu, T.-H.; T.-H.; Liu, C.-Y.; Lin, S.-Y.* J. Mater. Chem. B, 2015, 3, 191–197. (SCI: 4.872; 5-Year IF: 4.879; 2015 Rank: 4/33)
  12. "Co-caged gold nanoclusters and methyl motifs lead to detoxification of dendrimers and allow cytosolic access for siRNA transfection" Chien, C.-T.; Liu, C.-Y.; Wu, Z.-W.; Chen, P.-J.; Chu, C.-L.*; Lin, S.-Y.* J. Mater. Chem. B, 2014, 2, 6730–6737. (SCI: 4.726; 5-Year IF: 4.729; 2014 Rank: 6/33)
  13. "Live-Cell Imaging of Biothiols via Thiol/Disulfide Exchange to Trigger the Photoinduced Electron Transfer of Gold-Nanodot Sensor" Liu, C.-P.; Wu, T.-H.; T.-H.; Liu, C.-Y.; Lin, S.-Y.* Analytica Chimica Acta, 2014, 849, 57–63. (SCI: 4.513; 5-Year IF: 4.667; 2014 Rank: 5/74)
  14. "Fluorescent Hydroxylamine Derived from Fragmentation of PAMAM Dendrimers for Intracellular Hypochlorite Recognition" Wu, T.-H.; Jao, Y.-C.; Liu, C.-P.; Chien, C.-T.u Lin, S.-Y.* Cuhem. Eur. J. 2013, 19, 11672–11675. (SCI: 5.696; 5-Year IF: 5.218; 2013 Rank: 22/148)
  15. "Caged Pt nanoclusters exhibiting corrodibility to exert tumor-inside activation for anticancer chemotherapeutics" Chien, C.-T.; Yan, J.-Y.; Ching, W.-C.; Wu, T.-H.; Liu, C.-Y.; Lin, S.-Y.* Adv. Mater. 2013, 25, 5067–5073. (SCI: 15.409; 5-Year IF: 15.581; 2013 Rank: 7/148)
  16. "In-situ Formation and Assembly of Gold Nanoparticles by Gum Arabic as Efficient Photothermal Agent for Killing Cancer Cells" Liu, C.-P.; Lin, F.-S.; Chien, C.-T.; Tseng, S.-Y.; Luo, C.-W.; Chen, C.-H.; Chen, J.-K.; Tseng, F.-G.; Hwu, YK; Lo, L.-W.; Yang, C.-S.; Lin, S.-Y.* Macromol. Biosci. 2013, 13, 1314–1320. (SCI: 3.650; 5-Year IF: 3.955; 2013 Rank: 14/82)
  17. "Recent progress in copolymer-mediated siRNA delivery" Wu, Z-W.; Chien, C.-T.; Liu,C.-Y.; Yan, J.-Y.; Lin, S.–Y.* J. Drug Target. 2012, 20, 551–560. (Invited review) (SCI: 2.723; 5-Year IF: 2.706; 2013 Rank: 94/254)
  18. "Chemical auxiliary-free polymerization yielding non-linear PEG for protein-resistant application" Lin, F.-S.; Chiu, W.-C.; Chien, C.-T.; Lin, S.–Y.*; Tseng, F.-G.; Hwu, YK.; Yang, C-S. RSC Advances 2012, 2, 7174-7179. (SCI: 3.708; 5-Year IF: 3.708; 2013 Rank: 35/148)
  19. "A Redox-Switchable Au8-Cluster Sensor" Wu, T.-H.; Yu-Yen Hsu; Lin, S.–Y.* Small 2012, 8, 2099 -2105. (SCI: 7.514; 5-Year IF: 8.416; 2013 Rank: 17/251)
  20. "Unraveling the photoluminescence puzzle of PAMAM dendrimers" Lin, S.–Y.*; Wu, T.-H.; Jao, Y.-C.; Liu, C.-P.; Lin, H.-Y.; Lo, L.-W.; Yang, C.-S. Chem. Eur. J. 2011, 17, 7158–7161. (SCI: 5.831; 5-Year IF: 5.623; 2012 Rank: 21/152)
  21. "A single-monomer derived linear-like PEI-co-PEG for siRNA delivery and silencing" Tsai, L.-R.; Chen, M.-H.; Chien, C.-T.; Chen, M.-K.; Lin, F.-S.; Lin, Kurt M.-C.; Hwu, Y.-K.; Yang, C-S.* ; Lin, S.-Y.* Biomaterials 2011, 32, 3647–3653. (SCI: 7.604; 5-Year IF: 8.496; 2012 Rank: 3/79)
  22. "Enhanced Quantum Yield of Dendrimer-Entrapped Gold Nanodots by a Polarity-Specific Ion-Pair Association and Microwave Irradiation for Bioimaging" Jao, Y.-C.; Chen, M.-K.; Lin, S.-Y.* Chem. Commun. 2010, 46, 2626–2628. (SCI: 6.378; 5-Year IF: 6.226; 2012 Rank: 19/152)
  23. "One-Pot Synthesis of Linearlike and Photoluminescent Polyethylenimines for Intracellular Imaging and siRNA Delivery" Lin, S.-Y.*; Lin, F.-S.; Chen, M.-K; Tsai, L.-R.; Jao, Y.-C.; Lin, H.-Y.; Wang, C.-L.; Hwu, Y.-K.; Yang, C.-S.* Chem. Commun. 2010, 46, 5554–5556. (SCI: 6.378; 5-Year IF: 6.226; 2012 Rank: 19/152)
  24. "The Protease-mediated Nucleus Shuttles of Sub-nanometer Gold Quantum Dots for Real-time Monitoring of Apoptotic Cell Death" Lin, S.-Y.; Chen, N.-T.; Sun, S.-P.; Chang, Jerry C.; Wang, Y.-C.; Yang, C.-S.*; Lo, L.-W.* J. Am. Chem. Soc. 2010, 132, 8309–8315. (SCI: 10.677; 5-Year IF: 10.237; 2011 Rank: 11/152)
  25. "Ligand-exchanged Photoluminescent Gold Quantum Dots Functionalized with Leading Peptide for Nuclear Targeting and Intracellular Imaging", Lin, S.-Y.; Chen, N.-T.; Sum, S.-P.; Lo, Lo, L.-W.; Yang, C.-S. Chem. Commun. 2008, 4262-4764. (SCI: 6.169; 5-Year IF: 6.082; 2011 Rank: 19/154)

National Health Research Institutes - Institutional Repository: http://ir.nhri.org.tw/handle/3990099045/3715

Patent in NHRI

  1. "Method for making a ligand-quantum dot conjugate" US(USPTO) issued on 2012/07/10 with patent number: US8,216,549; Taiwan (ROC) filed on 2013/04/11 with patent number: I 392869,Lin, S.-Y. Lo, L.-W.; Yang, C.-S.
  2. "Single-monomer Derived Linear-like Copolymer Comprising synthesis of linear-like Polyethylenimine and Poly(ethylene glycol) for Nuclear Acid Delivery" US(USPTO) issued on 2013/06/11 with patent number: US8,4613,224; Taiwan (ROC) issued on 2014/2/11 with patent number I 426085.
  3. "Caged platinum nanocluster for anticancer chemotherapeutics" Lin. S-Y. US(USPTO), Taiwan, Australia, Canada, Europe and Japan have been granted.
  4. "Endotoxin Nanovesicles: Hydrophilic Gold Nanodots Control Lipopolysaccharide Assembly for Modulating Immunological Responses" US(USPTO)/Taiwan filed on 14/03/2016 and 03/03/2016 with filing number 15/069,946 and 105106483, respectively; Luo, -Y.-H.; Lin, S.-Y.; Lin, P.P.
  5. "Alkyl-Motif Gold Nanoclusters as the Endotoxin Inhibitor" US(USPTO)/Taiwan filed on 28/02/2018 and 27/03/2018 with filing number 15/069,946 and 105106483, respectively; Lin, S.-Y.
  6. "Lipopolysaccharide analogues to trigger non-equilibrium co-assembly and clearance of Aβ42" US Provisional Patent, application number: 63/113578.

Technology Transfer

2016 Caged Platinum Nanoclusters for Anticancer Chemotherapeutics