Education

• 1998 - 2002

  National Cheng Kung University, Taiwan

  Ph.D. in Mechanical Engineering
• 1996 - 1998

  National Cheng Kung University, Taiwan

  M.S. in Mechanical Engineering
• 1992 - 1996

  National Chiao Tung University, Taiwan

  B.S. in Mechanical Engineering

Professional Experiences

• 2021 - present

  Center for Functional Image and Interventional Therapy, National Taiwan University, Taiwan

  Advisory Committee Member
• 2021 - present

  Biotechnology Center, National Chung-Hsing University, Taiwan

  Jointly Appointed Professor
• 2021 - present

  Department of Mechanical Engineering, National United University, Taiwan

  Jointly Appointed Professor
• 2021 - present

  Institute of Biomedical Engineering, National Yang Ming Chiao Tung University, Taiwan

  Jointly Appointed Professor
• 2020 - present

  Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

  Investigator
• 2020 - 2021

  Institute of Biomedical Engineering, National Chiao-Tung University, Taiwan

  Jointly Appointed Associate Professor
• 2016 - 2021

  Department of Mechanical Engineering, National United University, Taiwan

  Jointly Appointed Associate Professor
• 2015 - 2021

  Biotechnology Center, National Chung-Hsing University, Taiwan

  Jointly Appointed Associate Professor
• 2014 - 2020

  Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

  Associate Investigator
• 2013 - 2014

  Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

  Assistant Investigator
• 2009 - 2013

  Division of Medical Engineering Research, National Health Research Institutes, Taiwan

  Assistant Investigator
• 2007 - 2008

  NIH Ultrasound Transducer Resources Center, University of Southern California, USA

  Visiting Scholar
• 2006 - 2009

  Division of Medical Engineering Research, National Health Research Institutes, Taiwan

  Research Associate
• 2006

  Department of Automatic Control Engineering, Feng Chia University, Taiwan

  Adjunct Assistant Professor
• 2002 - 2006

  Division of Medical Engineering Research, National Health Research Institutes, Taiwan

  Postdoctoral Fellow

Research Interests

Dr. Chen’s research interest is in ultrasonic transducers, imaging-guided focused ultrasound systems, focused ultrasound for tumor therapy, and ultrasonic neuromodulation.

Research Activities & Accomplishment

The strategy of Dr. Chen’s laboratory is to use the ultrasonic technology to create novel treatment modalities and devices for clinical diseases. The ultimate goal is to provide surgeons or clinicians a new tool to treat diseases which can’t be treated with current operations or to improve the efficacy of the treatment or to lower the surgical risk.

Selected Publications

1. H Chan, JJ Chen, WL Lin, and GS Chen* (2022). Large-volume focused-ultrasound mild hyperthermia for improving blood-brain tumor barrier permeability application. Pharmaceutics 14(10):2012.

2. JY Chiou, T Abd-Elrehim, CC Lin, and GS Chen* (2020). Feasibility study of greater occipital nerve blocks by focused ultrasound – animal study. Journal of Neural Engineering 17(5):056030.

3. LW Kuo, GC Dong, CC Pan, SF Chen, and GS Chen* (2020). An MRI-guided ring high-intensity focused ultrasound system for noninvasive breast ablation. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 67(9): 1839-1847.

4. JS Tan, CC Lin, JS Cheng, and GS Chen* (2020). High-intensity focused ultrasound ablation combined with electrical passive exercise for fast removal of body fat. Plastic and Reconstructive Surgery 145(6):1427-1438.

5. JS Tan, CC Lin, and GS Chen* (2020). Vasomodulation of peripheral blood flow by focused ultrasound potentiates improvement of diabetic neuropathy. BMJ Open Diabetes Research and Care 8(1):e001004.

6. JC Chen, HY Chang, JJ Chen, and GS Chen* (2019). A piezoceramic sensor for detection of focused ultrasound-induced cavitation. IEEE Sensors Journal 19(22): 10379-10385.

7. LW Kuo, LC Chiu, WL Lin, JJ Chen, GC Dong, SF Chen, and GS Chen* (2018). Development of an MRI-compatible high-intensity focused ultrasound phased array transducer dedicated for breast tumor treatment. IEEE Transactions on Ultrasonics Ferroelectrics and Frequency Control 65(8):1423-1432.

8. GC Dong, LC Chiu, CK Ting, JR Hsu, CC Huang, Y Chang, and GS Chen* (2017). A coaxial dual-element focused ultrasound probe for guidance of epidural catheterization: An experimental study. Ultrasonic Imaging 39(5):283-294.

9. LC Chiu, SK Wu, WL Lin*, and GS Chen* (2017). Synergistic effects of nanodrug, ultrasound hyperthermia and thermal ablation on solid tumors - an animal study. IEEE Transactions on Biomedical Engineering 64(12):2880-2889.

10. YF Lee, CC Lin, JS Cheng, and GS Chen* (2015). Nerve conduction blockage of diabetic rats by high-intensity focused ultrasound for analgesia applications. British Journal of Anaesthesia 114(5):840-846.

11. YF Lee, CC Lin, JS Cheng, and GS Chen* (2015). High-intensity focused ultrasound attenuates neural responses of sciatic nerves isolated from normal or neuropathic rats. Ultrasound in Medicine and Biology 41(1):132-142.

12. GS Chen*, YC Chang, Y Chang, and JS Cheng (2014). A prototype axial ultrasound needle guide to reduce epidural bone contact. Anaesthesia 69(7):746-751.

13. GS Chen*, YF Lee, and JS Cheng (2014). Measurement of ultrasonic attenuation in diabetic neuropathic sciatic nerves for diagnostic and therapeutic applications. Annals of Biomedical Engineering 42(8):1749-1759.

14. GS Chen*, CC Pan, YL Lin,and JS Cheng (2014). Assessing the relationship between the inter-rod coupling and the efficiency of piezocomposite high-intensity focused ultrasound transducers. Ultrasonics 54(3):789-794.

15. GS Chen*, HC Liu, YC Lin, and YL Lin (2013). Experimental analysis of 1-3 piezocomposites for high-intensity focused ultrasound transducer applications. IEEE Transactions on Biomedical Engineering 60(1):128-134.

16. GS Chen*, CY Lin, JS Jeong, JM Cannata, WL Lin, H Chang, and KK Shung (2012). Design and characterization of dual-curvature 1.5-dimensional high-intensity focused ultrasound phased-array transducer. IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control 59(1):150-155.

National Health Research Institutes - Institutional Repository: http://ir.nhri.org.tw/handle/3990099045/3807

Patent

1. Y Chang, and GS Chen. Inverted bowl shaped ultraosund probe structure of guiding the puncture needle. USA patent No. 10,376,280, 2019/08/13.
2. GS Chen, JS Cheng, and FH Lin. Apparatus for combining imaging ultrasonic probe and focused ultrasonic probe. ROC patent No. I658818, 2019/05/11.
3. GS Chen, LC Chiu, JJ Chen, and FH Lin. Therapeutic ultrasonic device and the use thereof. ROC patent No. I651109, 2019/02/21.
4. Y Chang, and GS Chen. An ultrasound probe structure. ROC patent No. I592141, 2017/07/21.
5. CC Lin, and GS Chen. Method and system for destroying adipose tissue non-invasively and accelerating lipid metabolism. USA patent No. 9,433,803, 2016/09/06.
6. CC Lin, and GS Chen. System for destroying adipose tissue non-invasively and accelerating lipid metabolism. ROC patent No. I507228, 2015/11/11.
7. GS Chen, H Chang, and WL Lin. Dual-curvature phased array high-intensity focused ultrasound transducer for tumor therapy. USA patent No. 8,888,706, 2014/11/18.