Education

• 2000 - 2004

  Department of Chemistry, National Tsing Hua University

  Ph.D. in Chemistry
• 1996 - 1998

  Department of Nuclear Science, National Tsing Hua University

  M.S. in Nuclear Science
• 1992 - 1996

  Department of Chemistry, National Tsing Hua University

  B.S. in Chemistry

Professional Experiences

• 2013.07 - present

  Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

  Assistant Investigator
• 2011.04 - 2013.07

  Center for Nanomedicine Research, NHRI, Taiwan

  Assistant Investigator
• 2011 - present

  School of Dentistry, National Defense Medical Center, Taipei, Taiwan

  Adjunct Assistant Professor
• 2007.04 - 2011.03

  Center for Nanomedicine Research, NHRI, Taiwan

  Postdoctoral Research Fellow
• 2005.05 - 2007.04

  Clinical Proteomics Center, Chang Gung Memorial Hospital, Taoyuan, Taiwan

  Research Associate
• 2004.09 - 2005.04

  Core Facility for Proteomics Research, Institute of Biochemistry, Academia Sinica, Taipei, Taiwan

  Postdoctoral Research Fellow
• 1997.07 - 2000.09

  Product Process and Chemistry Division, Food Industrial Research and Development Institute (FIRDI), Taiwan

  Associate Research Scientist

Research Interests

• Inhalation Medicine
• Radiopharmaceuticals for Imaging & Therapy
• NanoSafety
• BioAnalytical Chemistry: chromatography, mass spectrometry and imaging technology

Research Activities & Accomplishment

• 2013: The 10th National Innovation Award, “Treating Brain Tumor with Gold Nanoparticle Fusion Therapy”
• 2013: Supervisor of master student Ting-Yu Cheng (NTHU), won the “Outstanding Poster Award in the International Symposium of Chemical-Environmental-Biomedical Technology 2013 (Tohoku University, Sendai, Japan)”
• 2004: Outstanding award of Ph.D. dissertation in analytical/physical chemistry, Chinese Chemical Society, Taiwan.
• 1998: The Archilife research scholarship of master thesis in public health division, Archilife Research Foundation.
• 1996: Outstanding research award for under-graduated student, National Science Council, Taiwan.
• 1994: Outstanding student award, National Tsing Hua University.
• 1994, 1995 & 1996: Scholarship for undergraduate student, National Tsing Hua University.

Selected Publications

1. Chen, M.H.*, Lee, C.H., Liang, H.K., Huang, S.C., Li, J.P., Lin, C.J. & Chen, J.K.* Integrating the microneedles with carboplatin to facilitate the therapeutic effect of radiotherapy for skin cancers. Biomaterials Advances 141, 213113 (2022). doi: 10.1016/j.bioadv.2022.213113 (Formerly known as Materials Science and Engineering: C, with IF2021: 8.457, Journal ranking: 8/46 in MATERIALS SCIENCE, BIOMATERIALS, Quartile in Category: Q1) (Co-corresponding author) [領域屬性: 放射診療Radiotheranostics]

2. Qiu, S.B., Liu, P.Y., Wang, B.C., Chen, P.R., Xiao, J.H., Hsu, T.Y., Pan, K.L., Lai, Z.Y., Chen, Y.W., Chen, Y.C., Chen, J.K.* & Pan, P.S.* Protection-Free Strategy for the Synthesis of Boro-Depsipeptides in Aqueous Media under Microwave-Assisted Conditions. Molecules 27, 2325 (2022). doi: 10.3390/molecules27072325 (IF2021: 4.927, Journal ranking: 65/179 in CHEMISTRY, MULTIDISCIPLINARY, Quartile in Category: Q2; Journal Ranking: 114/296 in BIOCHEMISTRY & MOLECULAR BIOLOGY, Quartile in Category: Q2) (Co-corresponding author) [領域屬性: 放射診療Radiotheranostics]

3. Ho, H.M., Huang, C.Y., Yang, C.H., Liu, S.J., Chen, H.W., Yu, G.Y., Chen, J.K., Chuang, T.H. & Huang, M.H. Formulation of SARS-CoV-2 Spike Protein with CpG Oligodeoxynucleotides and Squalene Nanoparticles Modulates Immunological Aspects Following Intranasal Delivery. Pharmaceutics 14 (2022). doi: 10.3390/pharmaceutics14112539 [領域屬性: 奈米醫學及藥物傳輸Nanomedicine & Drug delivery]

4. Liao, W.N., You, M.S., Ulhaq, Z.S., Li, J.P., Jiang, Y.J., Chen, J.K. & Tse, W.K.F. Micro-CT analysis reveals the changes of bone mineral density in zebrafish craniofacial skeleton with age. Journal of Anatomy 242, 544-551 (2023). doi: 10.1111/joa.13780 (IF2021: 2.921, Journal Ranking: 4/21 in ANATOMY & MORPHOLOGY, Quartile in Category: Q1) [領域屬性: 生醫影像Biomedical imaging, CT]

5. Huang, C.J., Narasimha, G.V., Chen, Y.C., Chen, J.K. & Dong, G.C. Measurement of low concentration of micro-plastics by detection of bioaffinity-induced particle retention using surface plasmon resonance biosensors. Biosensors (Basel) 11 (2021). doi: 10.3390/bios11070219 (Year2020 IF: 5.519, Journal Ranking: 15/87 in CHEMISTRY, ANALYTICAL, Quartile in Category: Q1; Journal Ranking: 8/64 in INSTRUMENTS & INSTRUMENTATION, Quartile in Category: Q1; Journal Ranking: 42/106 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q2), 3 time cited [領域屬性: 塑膠微粒Microplastics]

6. Chen, T.Y., Chen, M.R., Liu, S.W., Lin, J.Y., Yang, Y.T., Huang, H.Y., Chen, J.K., Yang, C.S. & Lin, K.M. Assessment of Polyethylene Glycol-Coated Gold Nanoparticle Toxicity and Inflammation In Vivo Using NF-kappaB Reporter Mice. International Journal of Molecular Sciences 21, 8158 (2020). doi: 10.3390/ijms21218158 (IF2020: 5.924, Journal ranking: 67/295 in BIOCHEMISTRY & MOLECULAR BIOLOGY, Quartile in Category: Q1; Journal ranking: 49/178 in CHEMISTRY, MULTIDISCIPLINARY, Quartile in Category: Q2), 5 times cited [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

7. Liang, S.K., Hsu, C.C., Song, H.L., Huang, Y.C., Kuo, C.W., Yao, X., Li, C.C., Yang, H.C., Hung, Y.L., Chao, S.Y., Wu, S.C., Tsai, F.R., Chen, J.K., Liao, W.N., Cheng, S.C., Tsou, T.C. & Wang, I.C. FOXM1 is required for small cell lung cancer tumorigenesis and associated with poor clinical prognosis. Oncogene 40, 4847-4858 (2021). doi: 10.1038/s41388-021-01895-2 (Year2020 IF: 9.867, Journal Ranking: 29/295 in BIOCHEMISTRY & MOLECULAR BIOLOGY, Quartile in Category: Q1; Journal Ranking: 32/195 in CELL BIOLOGY, Quartile in Category: Q1; Journal Ranking: 12/176 in GENETICS & HEREDITY, Quartile in Category: Q1; Journal Ranking: 30/242 in ONCOLOGY, Quartile in Category: Q1), 15 times cited [領域屬性: 生醫影像Biomedical imaging, CT]

8. He, R.Y., Lai, X.M., Sun, C.S., Kung, T.S., Hong, J.Y., Jheng, Y.S., Liao, W.N., Chen, J.K., Liao, Y.F., Tu, P.H. & Huang, J.J. Nanoscopic insights of amphiphilic peptide against the oligomer assembly process to treat Huntington's disease. Advanced Science 7, 1901165 (2020). doi: 10.1002/advs.201901165 (IF2020: 16.806, Journal ranking: 13/178 in CHEMISTRY, MULTIDISCIPLINARY, Quartile in Category: Q1; Journal ranking: 18/334 in MATERIALS SCIENCE, MULTIDISCIPLINARY, Quartile in Category: Q1; Journal ranking: 9/106 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q1), 12 times cited, (MOST 105-2113-M-400-005) [領域屬性：生醫影像Biomedical imaging, PET]

9. Tien, C.Y., Li, J.P., Han, D., Li, Z., Fu, P.K., Chen, J.K.* & Tsai, C.J.* Development of a novel shallow liquid interface exposure system for MWCNT toxicity assessment. Chemical Research in Toxicology 32, 1925-1939 (2019). doi: 10.1021/acs.chemrestox.9b00067 (IF2020: 3.739, Journal Ranking: 28/62 in CHEMISTRY, MEDICINAL, Quartile in Category: Q2; Journal Ranking: 74/178 in CHEMISTRY, MULTIDISCIPLINARY, Quartile in Category: Q2; Journal Ranking: 38/93 in TOXICOLOGY, Quartile in Category: Q2), 1 time cited, (MOST 106-2113-M-400-006 & 107-2622-8-009-004-TE5) [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

10. Thanasekaran, P., Chu, C.H., Wang, S.B., Chen, K.Y., Gao, H.D., Lee, M.M., Sun, S.S., Li, J.P., Chen, J.Y., Chen, J.K.*, Chang, Y.H. & Lee, H.M.* Lipid-wrapped upconversion nanoconstruct /photosensitizer complex for near-infrared light-mediated photodynamic therapy. ACS Applied Materials & Interfaces 11, 84-95 (2019). doi: 10.1021/acsami.8b07760 (IF2020: 9.229, Journal Ranking: 44/334 in MATERIALS SCIENCE, MULTIDISCIPLINARY, Quartile in Category: Q1; Journal ranking: 21/106 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q1), 24 times cited, (MOST 101-2113-M-001-001-MY2; 103-2113-M-001-028-MY2) [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

11. Bai, K.J., Chuang, K.J., Chen, J.K., Hua, H.E., Shen, Y.L., Liao, W.N., Lee, C.H., Chen, K.Y., Lee, K.Y., Hsiao, T.C., Pan, C.H., Ho, K.F. & Chuang, H.C. Investigation into the pulmonary inflammopathology of exposure to nickel oxide nanoparticles in mice. Nanomedicine 14, 2329-2339 (2018). doi: 10.1016/j.nano.2017.10.003 (5-Year IF: 6.306, Journal ranking: 19/86 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q1; Journal ranking: 11/128 in MEDICINE, RESEARCH & EXPERIMENTA, Quartile in Category: Q1) [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

12. Chuang, H.C., Chuang, K.J., Chen, J.K., Hua, H.E., Shen, Y.L., Liao, W.N., Lee, C.H., Pan, C.H., Chen, K.Y., Lee, K.Y., Hsiao, T.C. & Cheng, T.J. Pulmonary pathobiology induced by zinc oxide nanoparticles in mice: A 24-hour and 28-day follow-up study. Toxicology and Applied Pharmacology 327, 13-22 (2017). doi: 10.1016/j.taap.2017.04.018 (5-Year IF: 4.006, Journal ranking: 52/256 in PHARMACOLOGY & PHARMACY and 15/92 in TOXICOLOGY, Quartile in Category: Q1)(5-Year IF: 4.006, Journal ranking: 15/92 in TOXICOLOGY, Quartile in Category: Q1) [領域屬性: 奈米安全及生醫影像Nanosafety & Biomedical imaging, SPECT]

13. Huang, Y.C.*, Li, R.Y., Chen, J.Y. & Chen, J.K.* Biphasic release of gentamicin from chitosan/fucoidan nanoparticles for pulmonary delivery. Carbohydrate Polymers 138, 114-122 (2016). doi: 10.1016/j.carbpol.2015.11.072 (5-Year IF: 5.287, Journal ranking: 2/71 in CHEMISTRY, APPLIED, Quartile in Category: Q1)(Journal ranking: 3/57 in CHEMISTRY, ORGANIC, Quartile in Category: Q1)(Journal ranking: 4/87 in POLYMER SCIENCE, Quartile in Category: Q1), 83 times cited, (MOST 103-2221-E-019-064(Yi-Cheng Huang) and MOST 101-2113-M-400-001-MY2 (Jen-Kun Chen) [領域屬性: 奈米醫學及藥物傳輸Nanomedicine & Drug delivery]

14. Sun, Z., Yang, L., Chen, K.F., Chen, G.W., Peng, Y.P., Chen, J.K., Suo, G., Yu, J., Wang, W.C. & Lin, C.H. Nano zerovalent iron particles induce pulmonary and cardiovascular toxicity in an in vitro human co-culture model. Nanotoxicology 10, 881-890 (2016). doi: 10.3109/17435390.2015.1133861 (5-Year IF: 6.327, Journal ranking: 4/92 in TOXICOLOGY, Quartile in Category: Q1), (5-Year IF: 6.327, Journal ranking: 16/86 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q1) [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

15. Chen, J.K.*, Ho, C.C., Chang, H., Lin, J.F., Yang, C.S., Tsai, M.H., Tsai, H.T. & Lin, P.* Particulate nature of inhaled zinc oxide nanoparticles determines systemic effects and mechanisms of pulmonary inflammation in mice. Nanotoxicology 9, 43-53 (2015). doi: 10.3109/17435390.2014.886740 (5-Year IF: 5.998, Journal ranking: 6/93 in TOXICOLOGY, Quartile in Category: Q1)(Journal ranking: 27/94 in NANOSCIENCE & NANOTECHNOLOGY, Quartile in Category: Q2), 52 times cited, [領域屬性: 奈米醫學及安全Nanomedicine & Nanosafety]

16. Chen, C.H., Lin, F.S., Liao, W.N., Liang, S.L., Chen, M.H., Chen, Y.W., Lin, W.Y., Hsu, M.H., Wang, M.Y., Peir, J.J., Chou, F.I., Chen, C.Y., Chen, S.Y., Huang, S.C., Yang, M.H., Hueng, D.Y., Hwu, Y., Yang, C.S.* & Chen, J.K.* Establishment of a trimodality analytical platform for tracing, imaging and quantification of gold nanoparticles in animals by radiotracer techniques. Analytical Chemistry 87, 601-608 (2015). doi: 10.1021/ac503260f (5-Year IF: 6.337, Journal ranking: 7/84 in CHEMISTRY, ANALYTICAL, Quartile in Category: Q1), 17 times cited, (MOST 101-2113-M-400-001-MY2 and 102-2113-M-007-010) [領域屬性: 奈米醫學及生醫影像Nanomedicine & Biomedical imaging, SPECT]

National Health Research Institutes - Institutional Repository: 5483

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