Education

• Department and Graduate Institute of Pharmacology, College of Medicine, NTU, Taiwan

  Ph.D. in Pharmacology
• Graduate Institute of Basic Medical Science, Chang-Gung University, Taiwan

  M.S. in Medical Science
• Department of Medical Technology, Taipei Medical University, Taiwan

  B.S. in Medical Technology

Professional Experiences

• 2013 - present

  Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes, Taiwan

  Associate Investigator
• 2010 - 2013

  Center for Nanomedicine Research, NHRI, Taiwan

  Associate Investigator
• 2006 - 2010

  Center for Nanomedicine Research, NHRI, Taiwan

  Assistant Investigator
• 2004 - 2006

  Stem Cell Research Center, NHRI, Taiwan

  Postdoctoral Fellow
• 2002 - 2004

  Department and Graduate Institute of Pharmacology, College of Medicine, NTU, Taiwan

  Postdoctoral Fellow

Research Interests

Dr. Huang's research interests focus on 1) the development of integrated application and new strategy for nanomedicine and stem cell biology, and 2) the development of novel nanocarriers for biomedical applications. His lab is trying to lead the impact of SPIO nanoparticles on stem cell attributes to favorable stem cell therapy and developing a novel system composed of red blood cell-derived vesicles (RDVs) for biomedical applications.

Research Activities & Accomplishment

• 2014 10th TienTe Lee Award
• 2013 Young Scientist Research Achievement Award, NHRI
• 2013 10th National Innovation Award (Academic Research Category)
• 2011 Wu Ta-You Memorial Award (吳大猷紀念獎), Taiwan NSC

Selected Publications

1. Wu, SH; Hsieh, CC; Hsu, SC; Yao, M; Hsiao, JK; Wang, SW; Lin, CP; Huang, DM. RBC-derived vesicles as a systemic delivery system of doxorubicin for lysosomal-mitochondrial axis-improved cancer therapy. Journal of Advanced Research.30: 185-196, 2021.

2. Hsieh, CC; Hsu, SC; Yao, M; Huang, DM. Cd9 upregulation-decreased ccl21 secretion in mesenchymal stem cells reduces cancer cell migration. International Journal of Molecular Sciences.22: Article number 1738, 2021.

3. L, SW; Lee, CH; Lin, MS; Chi, CW; Chen, YJ; Wang, GS; Liao, KW; Chiu, LP; Wu, SH; Huang, DM; Chen, L; Shen, YS. ZnO nanoparticles induced caspase-dependent apoptosis in gingival squamous cell carcinoma through mitochondrial dysfunction and p70S6K signaling pathway. International Journal of Molecular Sciences.21: Article number 1612, 2020.

4. Chung, TH; Hsu, SC; Wu, SH; Hsiao, JK; Lin, CP; Yao, M; Huang, DM. Dextran-coated iron oxide nanoparticle-improved therapeutic effects of human mesenchymal stem cells in a mouse model of Parkinson's disease. Nanoscale.10: 2998-3007, 2018.

5. Chung TH, Hsieh CC, Hsiao JK, Yao M, Hsu SC, Huang DM. Dextran-coated iron oxide nanoparticles turn protumor mesenchymal stem cells (MSCs) into antitumor MSCs. RSC Adv. 6: 45553-45561, 2016.

6. Chung TH, Hsiao JK, Yao M, Hsu SC, Liu HM, Huang DM. Ferucarbotran, a carboxydextran-coated superparamagnetic iron oxide nanoparticle, induces endosomal recycling, contributing to cellular and exosomal EGFR overexpression for cancer therapy. RSC Adv. 5: 89932-89939, 2015.

7. Wang LY, Shi XY, Yang CS, Huang DM. Versatile RBC-derived vesicles as nanoparticle vector of photosensitizers for photodynamic therapy. Nanoscale. 5: 416-421, 2013.

8. Chung TH, Hsiao JK, Hsu SC, Yao M, Chen YC, Wang SW, Mark Kuo YP, Yang CS, Huang DM. Iron oxide nanoparticle-induced epidermal growth factor receptor expression in human stem cells for tumor therapy. ACS Nano. 5: 9807-9816, 2011.

9. Chang M, Yang CS, Huang DM. Aptamer-conjugated DNA icosahedral nanoparticles as a carrier of doxorubicin for cancer therapy. ACS Nano. 5: 6156-6163, 2011.

10. Chien LY, Hsiao JK, Hsu SC, Yao M, Lu CW, Liu HM, Chen YC, Yang CS, Huang DM. In vivo magnetic resonance imaging of cell tropism, trafficking mechanism, and therapeutic impact of human mesenchymal stem cells in a murine glioma model. Biomaterials. 32: 3275-3284, 2011.

11. Chang M, Hsiao JK, Yao M, Chien LY, Hsu SC, Ko BS, Chen ST, Liu HM, Chen YC, Yang CS, Huang DM. Homologous RBC-derived vesicles as ultrasmall carriers of iron oxide for magnetic resonance imaging of stem cells. Nanotechnology. 21: 235103, 2010.

12. Chen YC, Hsiao JK, Liu HM, Lai IY, Yao M, Hsu SC, Ko BS, Chen YC, Yang CS, Huang DM. The inhibitory effect of superparamagnetic iron oxide nanoparticle (Ferucarbotran) on osteogenic differentiation and its signaling mechanism in human mesenchymal stem cells. Toxicol Appl Pharm. 245: 272-279, 2010.

National Health Research Institutes - Institutional Repository: http://ir.nhri.org.tw/handle/3990099045/640

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