In Vivo Mapping of The Human Brain Connectome

時間地點:10:30 am, Sep 29 (Thu), 2022; R1-B1122 Conference Room

研討講者:Ching-Po Lin, Ph.D.

September 16, 2022

Ching-Po Lin, Ph.D.

Institute of Neuroscience

National Yang Ming Chiao Tung University

      Ching-Po Lin, Ph.D.

       Distinguished Professor, 

Institute of Neuroscience, 

National Yang Ming Chiao Tung University, Taipei, Taiwan 


09/1996 - 01/2002 PhD, Division of Biomedical Engineering, Department of Electrical Engineering,National                                                    Taiwan University, Taiwan

09/1991 - 07/1993 MS, Institute of Biomedical Engineering, National Yang-Ming University, Taiwan

09/1987 - 07/1991 BS, Department of Physics, National Central University, Taiwan PROFESSIONAL


02/2018 - present Distinguished Professor, Institute of Neuroscience, National Yang Ming Chiao Tung                                                            University, Taiwan

02/2012 - present Professor (with Tenure), Institute of Neuroscience, National Yang-Ming University,                                                              Taiwan

02/2009 - 01/2012 Associate Professor (with Tenure), Institute of Neuroscience, National Yang Ming                                                              University, Taiwan

02/2004 - 01/2009 Assistant Professor, Institute of Neuroscience, National Yang-Ming University, Taiwan

02/2002 - 01/2004 Postdoctoral Fellow, Institute of Electrical Engineering, National Taiwan University,                                                            Taiwan

09/1995 - 06/1996 Network Engineer, Institute for Information Industry, Taiwan

09/1993 - 08/1995 Department Staff, National Health Research Institute, Taiwan 


08/2022 - present Associate Dean of General Affairs, National Yang Ming Chiao Tung University, Taiwan

02/2022 - present Deputy Director, Medical Device Innovation and Translation R&D Center, National                                                              Yang Ming Chiao Tung University, Taiwan

02/2016 - 01/2022 Deputy Director, Aging and Health Research Center, National Yang Ming Chiao Tung                                                        University, Taiwan

10/2008 - present Director, MRI Core Facility, National Yang Ming Chiao Tung University, Taiwan


2021 Future Tech Award, Ministry of Science and Technology, Taiwan

2020 National Innovation Award, Taiwan

2020 Professor with permanently exempt from assessment, National Yang Ming Chiao Tung University

2019 PAC Model Award, Predictive Analytics Competition

2016 Award for executing Innovative Research Grant 3 times, National Health Research Institute

2016 12th The G. Nappi Cluster Headache Award

2011 12th The G. Nappi Cluster Headache Award


1. Associate Editor: Brain Connectivity

2. Associate Editor: Frontiers in Neuroscience, Section in Brain Imaging Methods 

3. Editorial Board: Plos One 


1. Medical Research Council (MRC), UK (2017) 

2. Agence Nationale De La Recherche (ANR), France (2013, 2014) 

3. Ministry of Science and Technology, Taiwan (2000 – present) 


1. Committee member, Asian Society of Magnetic Resonance in Medicine (2021 - present) 

2. Committee member, Taiwan Magnetic Resonance Society (2020 - present) 

3. Program committee: Organization for Human Brain Mapping (2010, 2011) 


1. Development of micro brain surgery navigation system: Fusion of AI face recognition and brain image features for accurate positioning. MOST Emerging Technology Application Program (PI; 2022/1/1-2023/12/31; NTD 3,260,000) 

2. Mapping the human brain connectome: Bridging microscale and macroscale organization. MOST Brain Project (PI; 2021/1/1-2022/12/31; NTD 18,000,000)

3. Mapping the human connectome: Bridging microscale and macroscale connectomics of the human brain. MOST Pre-Brain Project (PI; 2019/6/1-2020/12/31; NTD 9,500,000) 

4. Cognitive Aging and Enhancement: Neural Basis of Scaffolding Theory of Aging and Cognition. MOST Brain and Cognitive Sciences Project (PI; 2018/1/1-2020/6/30; NTD 5,000,000)

5. Constructing Healthy Living in Super-Aged Society by Artificial Intelligence: From Geroprotective Intervention to Care Management. MOST (Co-PI; 2018/1/1-2021/12/31; NTD 60,000,000)

6. Brain network changes in first-episode schizophrenia progression: extension of imaging endophenotype. NHRI (PI; 2017/1/1-2019/12/31; NTD 7,500,000)


1. Patent Number: I 504382 (Taiwan) Title: A dental stimulator brain imaging Inventors: CP Lin, CP Jao Valid: 2015 - 2035 

2. Patent Number: I614627 (Taiwan) Title: A method for neural tracts tracking (It has been technology transferred) Inventors: CP Lin, CY Lo, CT Chong Valid: 2018 - 2037 

3. Patent Number: I679652 (Taiwan) Title: Method for individual brain morphometry assess Inventors: CP Lin, WC Lin, KH Chou Valid: 2019 - 2039 

4. Patent Number: 10,497,120B2 (USA) Title: Method and apparatus of fiber tracing, and non-transitory computer-readable medium Inventors: CP Lin, CY Lo, CT Chong, CC Huang (It has been technology transferred) Valid: 2019 - 2040 

5. Patent Number: I726574B (Taiwan) Title: Method for model training and electric device Inventors: CP Lin , LK Chen, KH Chou, CD Hsieh, CS Yu, SY Huang, MC Cheng Valid: 2020 - 2040 

6. Patent Number: approved, waiting for license (Taiwan) Title: Method for White matter-based neurovascular age prediction Inventors: CP Lin, CC Huang Valid: 2022- 2042


1. Multimodal Integration- Combining DTI and fcMRI, 7th Biennial Conference on Resting State Brain Connectivity, Dallas, Texas, USA (Sep, 2019)

2. Mapping the connectomics of human brain disorders, ISMRM, Montreal, Canada (May, 2019) 

3. Artificial intelligence in aging brain science, Shanghai innovation forum, Shanghai, China (Jul, 2018) 

4. Mapping the structural connections in the living human brain, IEEE EMBS Neural Engineering Summer School, Shanghai, China (Aug. 2017) 

5. Mapping the connectomics of human brain disorders, IEEE EMBS Neural Engineering Summer School, Shanghai, China (Aug. 2017) 

6. Diffusion MRI Tractography for Neurosurgery, WFNS 16th World Congress of Neurosurgery, Istanbul, Turkey (Aug. 2017) 

7. Reorganization of Brain Connectivity during Sleep, 1st Scientific and clinical meeting for sleep medicine, Suzhou, China (Nov. 2016) 

8. Multimodal Integration- Combining DTI and fcMRI, 5th Biennial Conference on Resting State Brain Connectivity, Vienna, Austria (Sep. 2016)


Total Number of Citations = 13863; H-Factor = 51

1. 1. Chu-Chung Huang, Kun-Hsien Chou, Wei-Ju Lee, Albert C. Yang, Shih-Jen Tsai, Liang-Kung Chen, Chih-Ping Chung*, Ching-Po Lin*. Brain white matter hyperintensities-predicted age reflects neurovascular health in middle-to-old aged subjects. Age & Ageing 2022 51(5):afac106 

2. Yi-Chia Kung, Chia-Wei Li, Fan-Chi Hsiao, Pei-Jung Tsai, Shuo Chen, Ming-Kang Li, Hsin-Chien Lee, Chun-Yen Chang, Changwei W. Wu, Ching-Po Lin*. Cross-scale Dynamicity of Entropy and Connectivity in the Sleeping Brain. Brain Connectivity 2022 (in press) 

3. Chih-Chin Heather Hsu, Shin Tai Chong, Yi-Chia Kung, Kuan-Tsen Kuo, Chu-Chung Huang, Ching-Po Lin*. Integrated Diffusion Image Operator (iDIO): A tool for automated configuration and processing of diffusion MRI data. bioRxiv 2022. 

4. Yi-Chia Wei, Yi-Chia Kung, Wen-Yi Huang, Chemin Lin, Yao-Liang Chen, Chih-Ken Chen, Yu-Chiau Shyu, Ching-Po Lin*. Functional Connectivity Dynamics Altered of the Resting Brain in Subjective Cognitive Decline. Frontiers in Aging Neuroscience, section Neurocognitive Aging and Behavior 2022 (In press) 

5. Yi-Chia Wei, Wen-Yi Huang, Chih-Yu Jian, Chih-Chin Heather Hsu, Chih-Chung Hsu, Ching-Po Lin, Chi-Tung Cheng, Yao-Liang Chen, Hung-Yu Wei, Kuan-Fu Chen. Semantic segmentation guided detector for segmentation, classification, and lesion mapping of acute ischemic stroke in MRI images. NeuroImage: Clinical 2022; 103044 

6. Chih-Ping Chung, Li-Ning Peng, Wei-Ju Lee, Pei-Ning Wang, Ching-Po Lin, Liang-Kung Chen. Cerebral small vessel disease is associated with concurrent physical and cognitive impairments at preclinical stage. Cerebral Circulation - Cognition and Behavior 2022; 3: 100144 

7. Mingrui Xia, Jin Liu, Andrea Mechelli, Xiaoyi Sun, Qing Ma, Xiaoqin Wang, Dongtao Wei, Yuan Chen, Bangshan Liu, Chu-Chung Huang, Yanting Zheng, Yankun Wu, Taolin Chen, Yuqi Cheng, Xiufeng Xu, Qiyong Gong, Tian-Mei Si, Shijun Qiu, Ching-Po Lin, Jingliang Cheng, Yanqing Tang, Fei Wang, Jiang Qiu, Peng Xie, Lingjiang Li, Yong He. Connectome Gradient Dysfunction in Major Depression and Its Association with Gene Expression Profiles and Treatment Outcomes. Molecular Psychiatry 27(3): 1384-1393 (2022) 

8. Chia-Shu Lin, Li-Kuo Liu, Wei-Ju Lee, Li-Ning Peng, Ching-Po Lin, Shyh-Yuan Lee, Liang-Kung Chen. Low masseter muscle mass is associated with frailty in community-dwelling older adults: I-Lan Longitudinal Aging Study. Experimental Gerontology 2022; 163:111777 

9. Kai Niu, Xueyan Li, Li Zhang, Zhensong Yan, Wei Yu, Peipeng Liang, Yan Wang, Ching-Po Lin, Huimao Zhang, Chunjie Guo, Kuncheng Li, Tianyi Qian. Improving segmentation reliability of multi-scanner brain images using a generative adversarial network. Quant Imaging Med Surg. 2022; 12(3):1775-1786 

10. Yi-Cheng Lin, Yun R Lien, Shang-Hua N. Lin, Yi-Chia Kung, Chu-Chung Huang, Ching-Po Lin, Li-Hung Chang Baseline cerebro-cerebellar functional connectivity in afferent and efferent pathways reveal dissociable improvements in visuomotor learning. Frontiers in Neuroscience 2022; 16: 904564 

11. Yun Lien, Yi-Cheng Lin, Shang-Hua N. Lin, Ching-Po Lin, Li-Hung Chang. Frequency-dependent effects of cerebellar rTMS on visuomotor accuracy. Frontiers in Neuroscience 2022; 16: 804027 

12. Chu-Chung Huang, Edmund T. Rolls, Jianfeng Feng, Ching-Po Lin. An extended Human Connectome Project multimodal parcellation atlas of the human cortex and subcortical areas. Brain Structure and Function 227(3): 763-778 (2022) 

13. I-Ting Lee, Chu-Chung Huang, Po-Cheng Hsu, Ching-Po Lin, Po-Yi Tsai. Resting-State Network Changes Following Transcranial Magnetic Stimulation in Patients with Aphasia-A Randomized Controlled Study. Neuromodulation: Technology at the Neural Interface 2022 25(4):528-537 

14. Po-Yuan Su, Yi-Chia Wei, Hao Luo, Chi-Hung Liu, Wen-Yi Huang, Kuan-Fu Chen, Ching-Po Lin, Hung-Yu Wei, Tsong-Hai Lee. Machine Learning Models for Predicting Influential Factors of Early Outcomes in Acute Ischemic Stroke: Registry-Based Study. JMIR Med Inform 2022;10(3):e32508 

15. Cheng-Chia Lee, Sheng-Che Hung, Yi-Hsiu Chen, Hsin-Hung Chen, Chien Chen, Ching-Jen Chen, Hsiu-Mei Wu, Ching-Po Lin, Syu-Jyun Peng. Structural connectivity in children after total corpus callosotomy. Epilepsy Research 2022; 182: 106908 

16. Tony Szu-Hsien Lee, Yi-Hsuan Liu, Yun-Ju Huang, Wai-Kwong Tang, Yifan Wang, Sien Hu, Ching-Po Lin, Chiang-Shan Ray Li, Chia-Chun Hung. Clinical and behavior characteristics of individuals who used ketamine. Scientific Reports 2022; 12(1):801 

17. Hung Yu Liu, Kun-Hsien Chou, Pei-Lin Lee, Yen-Feng Wang, Shih-Pin Chen, Kuan-Lin Lai, Ching-Po Lin, Shuu-Jiun Wang, Wei-Ta Chen. The right anterior insula is associated with pain generalization in patients with fibromyalgia. Pain 2022; 163(4):e572-e579 

18. Qiuyun Fan, Cornelius Eichner, Maryam Afzali, Lars Mueller, Chantal M.W. Tax, Mathias Davids, Mirsad Mahmutovic, Boris Keil, Berkin Bilgic, Kawin Setsompop, Hong-Hsi Lee, Qiyuan Tian, Chiara Maffei, Gabriel Ramos-Llordén, Aapo Nummenmaa, Thomas Witzel, Anastasia Yendiki, Yi-Qiao Song, Chu-Chung Huang, Ching-Po Lin, Nikolaus Weiskopf, Alfred Anwander, Derek K. Jones, Bruce R. Rosen, Lawrence L. Wald, Susie Y. Huang. Mapping the Human Connectome using Diffusion MRI at 300 mT/m Gradient Strength: Methodological Advances and Scientific Impact. Neuroimage 22;118958 (2022) 

19. Wei Zhao, Valerie Voon, Kangkang Xue, Chao Xie, Jujiao Kang, Ching-Po Lin, Jijun Wang, Jingliang Cheng, Jianfeng Feng. Common abnormal connectivity in first-episode and chronic schizophrenia in pre- and post-central regions: Implications for neuromodulation targeting. Prog Neuropsychopharmacol Biol Psychiatry 117: 110556 (2022) 

20. Chih-Ping Chung, Wei-Ju Lee, Kun-Hsien Chou, Pei-Lin Lee, Li-Ning Peng, Pei-Ning Wang, Ching-Po Lin, Liang-Kung Chen. Frailty and dementia risks in asymptomatic cerebral small vessel disease: A longitudinal cohort study. Archives of Gerontology and Geriatrics. 102: 104754 (2022) 

21. Yi-Cheng Lin, Chih-Ping Chung, Pei-Lin Lee, Kun-Hsien Chou, Li-Hung Chang, Szu-Ying Lin, Yi-Jung Lee, Ching-Po Lin, Pei-Ning Wang. The Flexibility of Physio-Cognitive Decline Syndrome: A Longitudinal Cohort Study. Front Public Health. 10: 820383 (2022) 

22. Yu Zhou, Xiaopeng Si, Yuanyuan Chen, Yiping Chao, Ching-Po Lin, Sicheng Li, Xingjian Zhang, Dong Ming , Qiang Li. Hippocampus- and Thalamus-Related Fiber-Specific White Matter Reductions in Mild Cognitive Impairment. Cerebral Cortex 2022; (in press) 

23. Yajuan Zhang, Qiong Xiang, Chu-Chung Huang, Jiajia Zhao, Yuchen Liu, Ching-Po Lin, Dengtang Liu*, Chun Yi Zac Lo*. Short-term Medication Effects on Brain Functional Activity and Network Architecture in First-Episode Psychosis: A Longitudinal fMRI Study. Brain Imaging Behav. (in press