“Borono-lectin”-inspired chemistry platform for bio-interactive DDS

時間地點:02:00 pm, Apr 18 (Thu), 2024; R1-B1122 Conference Room

研討講者:Akira Matsumoto, PhD

April 01, 2024


Boronic acids (BA) are able to reversibly interact with the diol groups, a commonly found motif in biomolecules including sugars, ribose and catechols. In some aspects, they optimally enhance the environmental stability of ribose, supporting a rationale for the "RNA world hypothesis," one of the theories of the origin of life. For their carbohydrate-binding properties, they can be regarded as a synthetic mimic of lectins, often termed “borono-lectins”. Remarkably, the borono-lectins platform can be chemically tailored to manifest a broad profile of binding strength and specificity. Besides the structural versatility, a pronounced change in water solubility accompanies some molecular-recognition events, enabling the "borono-lectins" to enjoy their complex and hierarchical functionalities. This feature, when combined with amphiphilic polymeric backbones, translates into many creative principles for fine-tuning or switching the hydration and more complex molecular assemblies in a way interactive with biology. I will provide a brief overview of our recent efforts on the related applications with focuses on smart insulin delivery systems1-4 and sialic acid detections relevant to cancer diagnosis and treatment5-7 among others.


[1] Siyuan Chen* et al., “Microneedle-Array Patch Fabricated with Enzyme-Free Polymeric Components Capable of On-Demand Insulin Delivery”, Adv. Funct. Mater., 2019, 29(7), 1807369. Web highlight [2] Akira Matsumoto* et al., “Hollow fiber-combined glucose-responsive gel technology as an in vivo electronics-free insulin delivery system”, Commun. Biol., 2020, 3, Article number: 313. [3] Akira Matsumoto* et al., “Synthetic “smart-gel” provides glucose-responsive insulin delivery in diabetic mice”, Sci. Adv. 2017, 3, eaaq0723. Web highlight [4] Akira Matsumoto et al., "A Synthetic Approach Toward Self-regulated Insulin Delivery System", Angew. Chem. Int. Ed. 2012, 51, 2124-2128. Inside Cover highlight [5] Takuya Miyazaki et al., "Boronic acid ligands can target multiple subpopulations of pancreatic cancer stem cells via pH-dependent glycan-terminal sialic acid recognition”. ACS Appl. Bio Mater. 4, 9, 6647–6651 (2021) [6] Thahomina Khan et al., "Structural Control of Boronic Acid Ligands Enhances Intratumoral Targeting of Sialic Acid to Eradicate Cancer Stem-Like Cells", ACS Appl. Bio Mater., 2020, 3(8), 5030–5039. [7] Akira Matsumoto* et al., “Heterocyclic Boronic Acids Display Sialic Acid Selective Binding under Hypoxic Tumor Relevant Acidic Environment”, Chem. Sci. 2017, 8, 6165-6170.

Akira Matsumoto, PhD

Institute of Biomaterials and Bioengineering (IBB)

Tokyo Medical and Dental Univ. (TMDU)

Akira Matsumoto, PhD

Akira Matsumoto is a Prof. in Institute of Biomaterials and Bioengineering (IBB) at Tokyo Medical and Dental Univ. (TMDU) where he directs the Organic Biomaterials group. He concurrently serves a Project Leader in Kanagawa Institute of Industrial Science and Technology (KISTEC) since 2017, a Vising Prof. in Dept. of Materials Engineering, The University of Tokyo since 2022, and a Representative Director and President of B-MED Co., Ltd. since 2021. B. Eng (1999) and Ph.D (2004) from the Univ. of Tokyo. 2004-2005: Postdoctoral fellow in a group of Prof. David L. Kaplan at Tufts Univ. 2006-2009: Assistant Prof. in Dept. of Bioengineering at the Univ. of Tokyo. 2010-2022: Associate Prof. and Research Prof. at IBB, TMDU. With a background on polymer materials science he has been interested in synthesis, design, functionalization and nano-/micro-fabrications of both synthetic and nature derived polymers. His recent research also focuses on development of solid-state biosensors. Among other honors he has been awarded the Nakatani Award in 2012 (Nakatani Foundation of Electronic Measuring Technology Advancement), TMDU Award for Excellence in Research (2013), Bioindustry Research Award in 2018 and SPSJ Asahi Kasei Award 2020.