The human DNA cytosine methyltransferase 3A (DNMT3A) is our current focus. This enzyme plays essential roles in early development, and occurs in stem cells in adults, and inappropriately, in cancer cells. DNA methylation at CpG sites controls the expression of proximal genes. Mutations in DNMT3A are some of the most common mutations in diverse cancers. Our interest is to understand how this enzyme is regulated by protein-protein interactions, histone modifications, and non-coding RNA. Our current model shows that non-coding RNA is a dominant form of regulation, although a large number of regulatory proteins as well as histone modifications play important roles as well. Our ultimate goal is to develop small molecules (inhibitors) that don’t show the toxicity of currently used DNMT3A inhibitors. Our recent discovery and design of allosteric inhibitors show exciting promise.
Human DNA methyltransferase: regulation and drug development
時間地點：02:00 pm, Mar 28 (Thu), 2024; R2-7042 Conference Room
研討講者：Norbert O. Reich, PhD
March 14, 2024
Norbert O. Reich, PhD
Department of Chemistry and Biochemistry
UC Santa Babara (UCSB)
Norbert O. Reich, PhD
Education
University of California, Berkeley B.S. Biochemistry 1975
San Francisco State University M.S., Biochemistry 1979
University of California, San Francisco Ph.D., Medicinal Chemistry 1984
Area of Specialization
Biochemistry, mechanistic enzymology, drug design, epigenetics, DNA methylation Chemical Biology tools for basic research and biomedical applications.
Previous Academic or Professional Appointments
1985-86 Postdoctoral Fellow University of California, San Francisco
1986-88 Assistant Professor II University of California, Santa Barbara
1988-91 Assistant Professor III University of California, Santa Barbara
1991-93 Assistant Professor IV University of California, Santa Barbara
1993-94 Associate Professor I University of California, Santa Barbara
1994-96 Associate Professor II University of California, Santa Barbara
1996-97 Associate Professor III University of California, Santa Barbara
1997-00 Professor I University of California, Santa Barbara
2000-03 Professor II University of California, Santa Barbara
2003-05 Professor III University of California, Santa Barbara
2005-07 Professor IV University of California, Santa Barbara
2007-09 Professor V University of California, Santa Barbara
2009-11 Professor VII University of California, Santa Barbara
2011-13 Professor VIII University of California, Santa Barbara
2013-2020 Professor IX University of California, Santa Barbara
2020- Distinguished Professor University of California, Santa Barbara
Professional Organizations
FASEB, ASBMB, ACS, Epigenetics Society
March 14, 2024
Norbert O. Reich, PhD
Department of Chemistry and Biochemistry
UC Santa Babara (UCSB)
Norbert O. Reich, PhD
Education
University of California, Berkeley B.S. Biochemistry 1975
San Francisco State University M.S., Biochemistry 1979
University of California, San Francisco Ph.D., Medicinal Chemistry 1984
Area of Specialization
Biochemistry, mechanistic enzymology, drug design, epigenetics, DNA methylation Chemical Biology tools for basic research and biomedical applications.
Previous Academic or Professional Appointments
1985-86 Postdoctoral Fellow University of California, San Francisco
1986-88 Assistant Professor II University of California, Santa Barbara
1988-91 Assistant Professor III University of California, Santa Barbara
1991-93 Assistant Professor IV University of California, Santa Barbara
1993-94 Associate Professor I University of California, Santa Barbara
1994-96 Associate Professor II University of California, Santa Barbara
1996-97 Associate Professor III University of California, Santa Barbara
1997-00 Professor I University of California, Santa Barbara
2000-03 Professor II University of California, Santa Barbara
2003-05 Professor III University of California, Santa Barbara
2005-07 Professor IV University of California, Santa Barbara
2007-09 Professor V University of California, Santa Barbara
2009-11 Professor VII University of California, Santa Barbara
2011-13 Professor VIII University of California, Santa Barbara
2013-2020 Professor IX University of California, Santa Barbara
2020- Distinguished Professor University of California, Santa Barbara
Professional Organizations
FASEB, ASBMB, ACS, Epigenetics Society