The basic function of this system is to provide double-isolated chamber preventing from unanticipated exposure while people handle nanomaterials. In addition to shielding capability, nano-aerosol generator coupled with real-time particle characterizing devices can quantitatively define physical parameters of target nano-materials for voluntary uptake and involuntary exposure. We are also interested in transdermal absorption as well as inhalation and ready to dedicate our efforts to initiate worldwide collaboration.