林名釗 博士

林名釗 博士

副研究員

辦公室分機 37118

實驗室分機 37119

Klin@nhri.edu.tw

實驗室網站 

Education

  • 1993 - 1998
    Department of Bioengineering, University of California, San Diego, USA
    Ph.D. in Bioengineering
  • 1987 - 1991
    Department of Mechanical Engineering, National Taiwan University, Taiwan
    B.S. in Mechanical Engineering

Professional Experiences

  • 2009.11 - present
    Division of Medical Engineering Research, National Health Research Institutes, Taiwan
    Associate Investigator
  • 2009.02 - present
    Department of Biomedical Imaging and Radiological Sciences (BIRS), National Yang Ming University, Taipei, Taiwan
    Adjunct Assistant Professor
  • 2003.08 - 2008.07
    Institute of Biomedical Engineering, National Yang Ming University, Taipei, Taiwan
    Adjunct Assistant Professor
  • 2001.11 - 2009.11
    Division of Medical Engineering Research, National Health Research Institutes, Taiwan
    Assistant Investigator
  • 1998.09 - 2001.10
    Division of Endocrinology and Metabolism, Lab of Professor Wolfgang Dillmann, MD, Department of Medicine, University of California, San Diego, La Jolla, CA, USA
    Postdoctoral Research Fellow

Research Interests

Dr. Lin's research interests include the following:
1. Inducible transgenic models and developing multimodal molecular imaging tools to be applied in a variety of disciplines, including cancer and inflammatory diseases
2. Regulatory roles of the stretching force in cell/tissue/organ development

Research Activities & Accomplishment

        The Lin lab is interested in applying bioengineering principles and technologies to studies in biomedicine, focusing on the areas of molecular imaging and mechanotransduction. Past projects on molecular imaging in Lin’s lab include the development of inducible transgenic mouse models and multimodal imaging reporter genes. These include transgenic mouse variants for specific functions such as EGFP/RFP switch color and inflammation mouse reporters. Multimodal reporters combining reporters of bioluminescence, fluorescence, nuclear, or magnetic resonance imaging in one mouse model were also developed to benefit from the complemented strengths of multiple imaging platforms. In addition, the Lin lab established primary mouse stem cells that specially express these multimodal reporter genes, created tumor models of breast and liver cancers, and developed mouse models for human diseases such as heart failure, atherosclerosis, muscle atrophy, obesity, and diabetes. Conditional transgenic mouse models (e.g. Cre/LoxP mice) were no exception.
        In the case of researching mechanotransduction of mesenchymal stem cells, a vivid research topic in tissue engineering, the Lin lab conducted studies on the regulatory roles of stretching forces in bone formation and on the modulation of stem cell properties. Our current project is to study the potential of combining tissue and genetic engineering approaches in order to enhance the quantity as well as the quality of ageing stem cells.

Selected Publications

  1. Lin K, Hollander JM, Kao V, Lian I, Lin B, Dillmann WH. Myocyte protection of rat neonatal cardiac myocytes death by 10 kD heat shock protein (Hsp10) involves the mobile loop and attenuation of Ras GTP-ase pathway. FASEB J. 10.1096/fj.03-0348fje, 2004.

  2. Hollander JM, Lin K, Scott B, Dillmann WH. Overexpression of PHGPx and HSP60/10 Protects against Ischemia/Reoxygenation Injury. Free Radical Biology & Medicine 35(7):742-751, 2003.

  3. Das DK, Dillmann W, Ho YS, Lin KM, Gloss BR. Using genetically engineered mice to study myocardial ischemia-reperfusion injury. Methods Enzymol 353:346-65, 2002.

  4. Lin K, Lin B, Lian I, Mestril R, Scheffler I, Dillmann WH. Combined and individual mitochondrial HSP60 and HSP10 expression in cardiac myocytes protects mitochondrial function and prevents apoptotic cell deaths induced by simulated ischemia-reoxygenation. Circulation 103:1787-1792, 2001.

  5. Lin K, Hsu PP, Chen BP, Yuan S, Usami S, Shyy JY, Li YS, Chien S Molecular mechanism of endothelial growth arrest by laminar shear stress. Proc Natl Acad Sci U S A. 97(17):9385-9, 2000.

  6. Lin M, Almus-Jacobs F, Chen H, Parry GC, Mackman N, Shyy JY, Chien S. Shear stress induction of the tissue factor gene. J. Clin. Invest. 99(4):737-44, 1997.

  7. Shyy JY, Lin MC, Han J, Lu Y, Petrime M, Chien S The cis-acting phorbol ester "12-O-tetradecanoylphorbol 13-acetate"-responsive element is involved in shear stress-induced monocyte chemotactic protein 1 gene expression. Proc Natl Acad Sci U S A. 92(17):8069-73, 1995.

National Health Research Institutes - Institutional Repository: 671