Advanced Metal-Organic Frameworks (MOFs) for Biomedical Engineering Applications
時間地點：10:30 am, Oct 03 (Mon), 2022; R1-B1122 Conference Room
研討講者：Chia-Wen Wu, Ph.D.
September 16, 2022
Chia-Wen Wu, Ph.D.
Department of Chemical Engineering
National Taiwan University
Chia-Wen Wu, Ph.D.
Distinguished Professor
Department of Chemical Engineering,
National Taiwan University, Taipei, Taiwan.
Education
2001-2005 Ph.D., Dept. of Mater. Sci. Eng., The University of Tokyo, Tokyo, Japan
1994-2000 B.S. & M.S., Dept. of Agri. Chem., National Taiwan University, Taipei, Taiwan
Current position and relevant experience
2022-present Jointly Appointed Professor, Biotechnology Center, National Taiwan University
2020-present Distinguished Professor, Dept. of Chem. Eng., National Taiwan University
2019-2021 Director, Division of Strategic Planning, Office of Research and Development,
National Taiwan University
2018-present Jointly Appointed Professor, Molecular Science & Technology, National Taiwan
Univ. (NTU-MST)
2016-present Professor, Dept. of Chem. Eng., National Taiwan University
2010-present Jointly Appointed Investigator, National Health Research Institutes, Taiwan
2014-2016 Secretary General, Taiwan Institute of Chemical Engineers
2012-2016 Associate Professor, Dept. of Chem. Eng., National Taiwan University
2013-2016 Vice chair, The Center of Strategic Materials Alliance for Research and Technology
(SMART Center), National Taiwan University, Taipei, Taiwan
2008-2012 Assistant Professor, Dept. of Chem. Eng., National Taiwan University
2006-2008 Post-doc, Dept. of Chem., Iowa State Univ., Iowa, USA
2005-2006 Post-doc, Dept. of Applied Chem., Waseda Univ., Tokyo, Japan
Records and achievements in education
2019 Best mentor in National Taiwan University
2008-2022 I have supervised 12 PhD students and 8 post-docs
Major awards and honours
2012: Career Development Research Funding Recipient from National Taiwan University.
2012: Young Scientists Research Funding Recipient from National Science Council, Taiwan.
2012: Young Investigator Award (YIA), The 2nd International Symposium of Materials on Regenerative Medicine, 2012 (ISOMRM 2012).
2014: The Distinguished Lectureship Award, The CSJ Asian International Symposium, Nagoya, Japan.
2015: Wu Da-Yu Award, Ministry of Science and Technology (MOST), Taiwan.
2016: The SCEJ Award for Outstanding Asian Researcher and Engineer.
2017: Outstanding Young Chemist Award, Chemistry Society of Taiwan.
2018: Humboldt scholars, Research Fellowship for Experienced Researchers from Alexander von Humboldt Foundation, Germany, 2018-2020.
2018: Outstanding Research Award, Ministry of Science and Technology, Taiwan.
2019: ACS Sustainable Chemistry & Engineering Lectureship Award (ACS)
2019: Outstanding Researcher Award (Asia-Pacific Association of Catalysis Societies; APACS)
2019: Outstanding Young Scholar Award, LCY Education Foundation.
2020: Outstanding Research Award, Ministry of Science and Technology, Taiwan.
2021: Clarivate Highly Cited Researchers (Cross-fields)
Editor/Editorial Board Members
2017: Associate Editor/Editorial Board, Journal of the Taiwan Institute of Chemical Engineers (Elsevier), IF: 4.794.
2018: Advisory Editorial Board Members, ACS Sustainable Chemistry & Engineering (ACS), IF:7.632.
2019: Editorial Board Members, Applied Catalysis B: Environmental (Elsevier), IF: 16.683.
2019: Editorial Board Members, Polymers (MDPI), IF: 3.164.
2021: International Advisory Board Members, ChemCatChem (Wiley-VCH; IF: 4.853).
2022: Editorial Board Members, Chemistry – An Asian Journal (Wiley-VCH; IF: 4.568).
2022: Associate Editor, Chemical Engineering Journal (Elsevier, IF: 13.07).
Statement of Research Expertise
My research interests and expertise are the structural design of functional nanoporous materials forbiomedical applications. Since I started my own career in NTU in 2008, I have focused on the synthesis and functionalization of mesoporous inorganic (silica, titania, gold, iron oxide, hydroxyapatite, etc.) and organic (alginate and chitosan) nanocomposites for intracellular drug delivery of bladder and liver cancers, controlled release of glaucoma, and bone healing. These works were summarized at my recent paper published in Adv. Mater. (2020, 1907035). Currently, I also start working on the design and synthesis of nanoporous metal-organic frameworks (MOFs) for various kinds of biomedical applications. For examples, water-based synthesis of MOFs for enzyme immobilization published in JACS (2015, 137(13), 4276-4279 and 2017, 139(19), 6530-6533) first demonstrates size-selective sheltering of catalase in biocatalysis application, conducting MOFs for biosensing of dopamine published in Adv. Sci. (2017, 4, 1700261) show an enhanced sensitivity and selectivity toward dopamine, Fe-based MOF for photothermal therapy published in ACS AMI (2021, 13(44), 52092-52105) demonstrates a monocyte and gold nanorods co-functionalized MOF can show an excellent antitumor efficacy from the histology of tumor tissues, survival rates, and bioluminescence imaging. The goal of my research is to develop a platform including various kinds of nanoporous biomaterials for both fundamental investigations of challenging problems and practical applications of biomaterials-based devices. I believe that I have an excellent publication track record with 240 peer-reviewed publications, 17700 times citation, and a H-index of 69. In addition, my ability to develop innovative ideas and commercialize research is evidenced by eight fully authorized patents and one technology transfer. For example, one of the technology developed at his laboratory“Functionalized mesoporous silica nanoparticles for tooth bleaching”, is protected by a patent (Patent No.: I461216), Authorization Duration: 2014/11/21~2030/12/08. This patent has been successfully licensed to a Taiwanese company (Wokan Co., Ltd.).
Selected Five Representative Publications
• Imparting Functionality to Biocatalysts via Embedding Enzymes into Nanoporous Materials by a de novo Approach: Size-Selective Sheltering of Catalase in Metal-Organic Framework Microcrystals. Journal of the American Chemical Society. 2015, 137(13), 4276-4279.
• Enhanced Charge Collection in MOF-525-PEDOT Nanotube Composite Enable Highly Sensitive Biosensing. Advanced Science. 2017, 4, 1700261.
• Biocompatible and Multifunctional Gold Nanorods for Effective Photothermal Therapy of Oral Squamous Cell Carcinoma. Journal of Materials Chemistry B. 2019, 7, 4451.
• Nanoarchitecting Structure and Surface Bio-functionality of Mesoporous Silica Nanoparticles (MSNs). Advanced Materials. 2020, 1907035.
• MCP-1 Functionalized, Core-Shell Gold Nanorod@Iron Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. ACS Applied Materials & Interfaces. 2021, 13(44), 52092-52105.
Chia-Wen Wu, Ph.D.
Department of Chemical Engineering
National Taiwan University
Chia-Wen Wu, Ph.D.
Distinguished Professor
Department of Chemical Engineering,
National Taiwan University, Taipei, Taiwan.
Education
2001-2005 Ph.D., Dept. of Mater. Sci. Eng., The University of Tokyo, Tokyo, Japan
1994-2000 B.S. & M.S., Dept. of Agri. Chem., National Taiwan University, Taipei, Taiwan
Current position and relevant experience
2022-present Jointly Appointed Professor, Biotechnology Center, National Taiwan University
2020-present Distinguished Professor, Dept. of Chem. Eng., National Taiwan University
2019-2021 Director, Division of Strategic Planning, Office of Research and Development,
National Taiwan University
2018-present Jointly Appointed Professor, Molecular Science & Technology, National Taiwan
Univ. (NTU-MST)
2016-present Professor, Dept. of Chem. Eng., National Taiwan University
2010-present Jointly Appointed Investigator, National Health Research Institutes, Taiwan
2014-2016 Secretary General, Taiwan Institute of Chemical Engineers
2012-2016 Associate Professor, Dept. of Chem. Eng., National Taiwan University
2013-2016 Vice chair, The Center of Strategic Materials Alliance for Research and Technology
(SMART Center), National Taiwan University, Taipei, Taiwan
2008-2012 Assistant Professor, Dept. of Chem. Eng., National Taiwan University
2006-2008 Post-doc, Dept. of Chem., Iowa State Univ., Iowa, USA
2005-2006 Post-doc, Dept. of Applied Chem., Waseda Univ., Tokyo, Japan
Records and achievements in education
2019 Best mentor in National Taiwan University
2008-2022 I have supervised 12 PhD students and 8 post-docs
Major awards and honours
2012: Career Development Research Funding Recipient from National Taiwan University.
2012: Young Scientists Research Funding Recipient from National Science Council, Taiwan.
2012: Young Investigator Award (YIA), The 2nd International Symposium of Materials on Regenerative Medicine, 2012 (ISOMRM 2012).
2014: The Distinguished Lectureship Award, The CSJ Asian International Symposium, Nagoya, Japan.
2015: Wu Da-Yu Award, Ministry of Science and Technology (MOST), Taiwan.
2016: The SCEJ Award for Outstanding Asian Researcher and Engineer.
2017: Outstanding Young Chemist Award, Chemistry Society of Taiwan.
2018: Humboldt scholars, Research Fellowship for Experienced Researchers from Alexander von Humboldt Foundation, Germany, 2018-2020.
2018: Outstanding Research Award, Ministry of Science and Technology, Taiwan.
2019: ACS Sustainable Chemistry & Engineering Lectureship Award (ACS)
2019: Outstanding Researcher Award (Asia-Pacific Association of Catalysis Societies; APACS)
2019: Outstanding Young Scholar Award, LCY Education Foundation.
2020: Outstanding Research Award, Ministry of Science and Technology, Taiwan.
2021: Clarivate Highly Cited Researchers (Cross-fields)
Editor/Editorial Board Members
2017: Associate Editor/Editorial Board, Journal of the Taiwan Institute of Chemical Engineers (Elsevier), IF: 4.794.
2018: Advisory Editorial Board Members, ACS Sustainable Chemistry & Engineering (ACS), IF:7.632.
2019: Editorial Board Members, Applied Catalysis B: Environmental (Elsevier), IF: 16.683.
2019: Editorial Board Members, Polymers (MDPI), IF: 3.164.
2021: International Advisory Board Members, ChemCatChem (Wiley-VCH; IF: 4.853).
2022: Editorial Board Members, Chemistry – An Asian Journal (Wiley-VCH; IF: 4.568).
2022: Associate Editor, Chemical Engineering Journal (Elsevier, IF: 13.07).
Statement of Research Expertise
My research interests and expertise are the structural design of functional nanoporous materials forbiomedical applications. Since I started my own career in NTU in 2008, I have focused on the synthesis and functionalization of mesoporous inorganic (silica, titania, gold, iron oxide, hydroxyapatite, etc.) and organic (alginate and chitosan) nanocomposites for intracellular drug delivery of bladder and liver cancers, controlled release of glaucoma, and bone healing. These works were summarized at my recent paper published in Adv. Mater. (2020, 1907035). Currently, I also start working on the design and synthesis of nanoporous metal-organic frameworks (MOFs) for various kinds of biomedical applications. For examples, water-based synthesis of MOFs for enzyme immobilization published in JACS (2015, 137(13), 4276-4279 and 2017, 139(19), 6530-6533) first demonstrates size-selective sheltering of catalase in biocatalysis application, conducting MOFs for biosensing of dopamine published in Adv. Sci. (2017, 4, 1700261) show an enhanced sensitivity and selectivity toward dopamine, Fe-based MOF for photothermal therapy published in ACS AMI (2021, 13(44), 52092-52105) demonstrates a monocyte and gold nanorods co-functionalized MOF can show an excellent antitumor efficacy from the histology of tumor tissues, survival rates, and bioluminescence imaging. The goal of my research is to develop a platform including various kinds of nanoporous biomaterials for both fundamental investigations of challenging problems and practical applications of biomaterials-based devices. I believe that I have an excellent publication track record with 240 peer-reviewed publications, 17700 times citation, and a H-index of 69. In addition, my ability to develop innovative ideas and commercialize research is evidenced by eight fully authorized patents and one technology transfer. For example, one of the technology developed at his laboratory“Functionalized mesoporous silica nanoparticles for tooth bleaching”, is protected by a patent (Patent No.: I461216), Authorization Duration: 2014/11/21~2030/12/08. This patent has been successfully licensed to a Taiwanese company (Wokan Co., Ltd.).
Selected Five Representative Publications
• Imparting Functionality to Biocatalysts via Embedding Enzymes into Nanoporous Materials by a de novo Approach: Size-Selective Sheltering of Catalase in Metal-Organic Framework Microcrystals. Journal of the American Chemical Society. 2015, 137(13), 4276-4279.
• Enhanced Charge Collection in MOF-525-PEDOT Nanotube Composite Enable Highly Sensitive Biosensing. Advanced Science. 2017, 4, 1700261.
• Biocompatible and Multifunctional Gold Nanorods for Effective Photothermal Therapy of Oral Squamous Cell Carcinoma. Journal of Materials Chemistry B. 2019, 7, 4451.
• Nanoarchitecting Structure and Surface Bio-functionality of Mesoporous Silica Nanoparticles (MSNs). Advanced Materials. 2020, 1907035.
• MCP-1 Functionalized, Core-Shell Gold Nanorod@Iron Based Metal-Organic Framework (MCP-1/GNR@MIL-100(Fe)) for Photothermal Therapy. ACS Applied Materials & Interfaces. 2021, 13(44), 52092-52105.