A conducting polymer, poly(3,4-ethylene dioxythiophene) or PEDOT, has been demonstrated in various biomedical applications, ranging from biosensing to medical bionics. We are especially interested in the development of antifouling PEDOT, which can resist nonspecific protein binding and cell adhesion. In this presentation, I will explain our strategies to manipulate the surface properties of PEDOT toward antifouling surfaces. Polymers functionalized with antifouling moieties, such as oligo(ethylene glycol) (OEG) and phosphorylcholine (PC), can resist nonspecific protein binding and cell adhesion. We have developed several type of antifouling PEDOT, including OEG-functionalized PEDOT and zwitterionic PC-functionalized PEDOT. The antifouling properties of conducting polymers grafted with OEG and PC groups will be illustrated and compared. A special focus on the antifouling properties under a surface potential will be presented. To investigate both specific and nonspecific protein adsorption on electrified electrodes, we measured the binding behavior of C-reactive protein (CRP), bovine serum albumin, and lysozyme on electrified and functionalized PEDOT by using an electrochemical quartz crystal microbalance with dissipation (EQCM-D) and electrochemical atomic force microscopy (EC-AFM). Other bio-related applications of antifouling conducting polymers will also be introduced in this presentation.
Shyh- Chyang Luo, Ph. D. (羅世強副教授)
Department of Materials Science and Engineering,
National Taiwan University
Shyh-Chyang Luo received his B.S. in Chemistry (1992 - 1996) and M.S. in Materials Science and Engineering (1996 - 1998) from National Taiwan University. After he finished his military service in Taiwan, he then went to United States in 2001 to pursue his Ph.D. degree. He received his Ph.D. degree from the Department of Materials Science and Engineering, University of Florida in 2005.
Although the focus of his Ph.D. dissertation was mainly on light-emitting polymers and light-emitting devices, he found he is more interested in the field of bioengineering applications. Therefore, after he received his Ph.D. degree, he decided to do his postdoctoral research at Institute of Bioengineering and Nanotechnology in Singapore to explore the field of conducting polymers for electrochemical biosensors (2006 - 2009). After that, he joined RIKEN in Japan as a research scientist. During his stay in Japan (2009 - 2013), he successfully received Grant-in-Aid for Young Scientist (KAKENHI) from Japan Society for Promotion of Science (JSPS) as a principal investigator to conduct independent research focused on the capture of rare cells. In 2015, he started his research career in the Department of Materials Science and Engineering at National Taiwan University.
Dr. Luo has published more than 30 SCI papers in the field of conducting polymers for bio-related applications. In 2013, he was invited to be as a guest editor of a top journal in polymer science, Polymer Reviews, to organize a special issue “conducting polymers as biomaterials and biointerfaces”. Dr. Luo is especially interested in the field of antifouling and conductive biomaterials. He was also invited by ACS Applied Materials & Interfaces to publish a review paper entitled “Engineering Antifouling Conducting Polymers for Modern Biomedical Applications” in 2019. Dr. Luo was awarded by The Society of Polymer Science, Japan “SPSJ Invited lecturer of International Leading Young Scientist” in 2018. His current research interests include organic conducting materials, bio-interfaces, electrochemical biosensors, polymer physics, and stimuli-responsive polymers.