Developing effective and safe treatment strategies for brain disorders, such as dementia, Alzheimer’s disease (AD), and Parkinson’s disease (PD), remains a challenge in the field of clinical application. AD is the most common form of dementia that has no cure. Transcranial ultrasound stimulation (TUS) is capable of stimulating intact brain circuitry and promoting levels of brain-derived neurotrophic factor (BDNF), an important regulator of long-term memory. Moreover, animal studies showed that TUS attenuated memory impairment as well as amyloidogenesis via the suppression of neuroinflammatory activity and BDNF decline. Our findings suggest that TUS could be a novel therapeutic technique for the treatment of neuroinflammation and associated neurodegenerative diseases.
Feng-Yi Yang, Ph.D. (楊逢羿 特聘教授 )
Biomedical Imaging and Radiological Sciences,National Yang-Ming University
Feng-Yi Yang was born and grew up in Taipei, Taiwan. He received the B.S. degree in electrical engineering from National Chiao Tung University, Hsinchu, Taiwan, in 1993, and the M.S. and Ph.D. degrees from National Yang-Ming University and National Taiwan University, Taipei, Taiwan, in 1997, and 2007, respectively, all in biomedical engineering. Dr. Yang was an assistant professor since 2008 and is now a distinguished professor in the Department of Biomedical Imaging and Radiological Sciences, School of Biomedical Science and Engineering, National Yang-Ming University, Taipei, Taiwan. His research interests are primarily concerned with therapeutic ultrasound, ultrasound neuromodulation, ultrasound drug delivery, biomedical engineering, medical imaging, and medical physics. He received the Future Tech Breakthrough Award (2018) from Ministry of Science and Technology, Academia Sinica Research Award (2013) for Junior Researchers from Academia Sinica of Taiwan, National Innovation Award (2012) from Institute for Biotechnology and Medicine Industry of Taiwan, Academic Achievement Award (2011-2020) from National Yang Ming University.